Acyclovir
Treatment for Genital Herpes
Typical Dosage: Episodic: 200mg 5x/day or 400mg 3x/day; Suppressive: 400mg 2x/day
Effectiveness
85%
Safety Score
78%
Clinical Trials
59
Participants
60K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
78
DangerousModerateSafe
Treatment Details
Dosage Range
Episodic: 200mg 5x/day or 400mg 3x/day; Suppressive: 400mg 2x/day
Time to Effect
Days to weeks
Treatment Duration
Episodic: 5-10 days; Suppressive: 6-12 months to indefinite
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
500(Treat 500 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$300
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$10,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$625
Cost per Remission
$833
Prescription Access Economics
Annual Societal Loss per Patient
$200
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$30/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$300/year
Potential OTC Price
$100/year
Estimated if OTC available
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEAcyclovir Outcomes
for Genital Herpes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+80%
Remission Rate
+60%
Common Side Effects
Headache
+15%
Nausea
+10%
Diarrhea
+5%
Vomiting
+3%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
18 completed trials for Acyclovir in Genital Herpes
HSV-2 Shedding Resolution After Acyclovir Treatment
NCT00495573COMPLETED
36 participants
OBSERVATIONAL
Seattle, United States
Started: Jun 1, 2007
A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation
NCT00723229COMPLETEDPHASE4
48 participants
INTERVENTIONAL
Seattle, United States
Started: Aug 1, 2008
Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes
NCT01281007COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Porto Alegre, Brazil +8 more
Started: Jul 1, 2012
Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2
NCT00362297COMPLETEDPHASE4
31 participants
INTERVENTIONAL
Seattle, United States
Started: Sep 1, 2006
Melatonin Effects on Genital Herpes in Brazilian Women
NCT03831165COMPLETEDPHASE4
90 participants
INTERVENTIONAL
São Paulo, Brazil +1 more
Started: Sep 2, 2015
GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women
NCT00808405COMPLETEDNA
88 participants
INTERVENTIONAL
Johannesburg, South Africa +1 more
Started: Jan 1, 2009
Acyclovir Therapy for Genital Herpes Ulcers in HIV Negative African Women
NCT02053142COMPLETEDNA
74 participants
INTERVENTIONAL
Lusaka, Zambia
Started: Jan 1, 2009
Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV
NCT00527618COMPLETEDPHASE4
28 participants
INTERVENTIONAL
Seattle, United States
Started: Dec 1, 2007
Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)
NCT00158483COMPLETEDPHASE2
449 participants
INTERVENTIONAL
Bangui, Central African Republic +2 more
Started: May 1, 2003
A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes
NCT00076232COMPLETEDPHASE3
3.68K participants
INTERVENTIONAL
San Francisco, United States +2 more
Started: Apr 1, 2005
Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda
NCT00405821COMPLETEDPHASE2
440 participants
INTERVENTIONAL
Kalisizo, Uganda
Started: Nov 1, 2006
Episodic Acyclovir Therapy for Genital Ulcers
NCT00164424COMPLETEDPHASE2, PHASE3
613 participants
INTERVENTIONAL
Johannesburg, South Africa +1 more
Started: Mar 1, 2005
The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood
NCT00001115COMPLETEDNA
75 participants
INTERVENTIONAL
Palo Alto, United States +14 more
Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons
NCT01026454COMPLETEDPHASE4
32 participants
INTERVENTIONAL
Thika, Kenya
Started: Feb 1, 2010
Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission
NCT00194519COMPLETEDPHASE3
3.41K participants
INTERVENTIONAL
Gabarone, Botswana +12 more
Started: Nov 1, 2004
Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2
NCT01346475COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Seattle, United States
Started: Nov 1, 2008
Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes
NCT00306787COMPLETEDPHASE3
1.18K participants
INTERVENTIONAL
Birmingham, United States +65 more
Started: Mar 1, 2006
Special Drug Use Investigation for VALTREX (Valaciclovir) (Suppression Prophylaxis)
NCT01390805COMPLETED
462 participants
OBSERVATIONAL
Started: Nov 1, 2006
Showing 20 of 59 total trials