Famciclovir
Treatment for Genital Herpes
Typical Dosage: Episodic: 1g 2x/day for 1 day; Suppressive: 250mg 2x/day
Effectiveness
87%
Safety Score
76%
Clinical Trials
7
Participants
35K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
76
DangerousModerateSafe
Treatment Details
Dosage Range
Episodic: 1g 2x/day for 1 day; Suppressive: 250mg 2x/day
Time to Effect
Days to weeks
Treatment Duration
Episodic: 1 day; Suppressive: 6-12 months to indefinite
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
500(Treat 500 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$320
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$520
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$16,000/QALY
QALYs Gained
0.055
Outcome-Based Costs
Cost per Responder
$650
Cost per Remission
$800
Comparison vs Acyclovir
Cost Difference
+$20/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$200
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$30/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$320/year
Potential OTC Price
$110/year
Estimated if OTC available
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEFamciclovir Outcomes
for Genital Herpes
Efficacy Outcomes
Overall Effectiveness
+87%
Response Rate
+80%
Remission Rate
+65%
Common Side Effects
Headache
+20%
Nausea
+8%
Diarrhea
+4%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
7 completed trials for Famciclovir in Genital Herpes
A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding
NCT00129818COMPLETEDPHASE4
INTERVENTIONAL
Birmingham, United States +6 more
Started: Jul 1, 2004
Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes
NCT01281007COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Porto Alegre, Brazil +8 more
Started: Jul 1, 2012
Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients
NCT00477334COMPLETEDPHASE4
463 participants
INTERVENTIONAL
Burbank, United States +42 more
Started: Jun 1, 2007
Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes
NCT00306787COMPLETEDPHASE3
1.18K participants
INTERVENTIONAL
Birmingham, United States +65 more
Started: Mar 1, 2006
Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes
NCT00171990COMPLETEDPHASE3
1.46K participants
INTERVENTIONAL
North Ryde, Australia
Started: Jan 1, 2003
RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir
NCT00219310COMPLETEDPHASE4
INTERVENTIONAL
East Hanover, United States
Started: Jun 1, 2003
Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes
NCT01154543COMPLETED
42 participants
OBSERVATIONAL
Started: Mar 1, 2008