Vaginal Estrogen (Topical)
Treatment for Genital Prolapse
Typical Dosage: 0.5g applicator 2-3 times/week or vaginal ring/tablet (various doses)
Effectiveness
55%
Safety Score
90%
Clinical Trials
100
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe
Treatment Details
Dosage Range
0.5g applicator 2-3 times/week or vaginal ring/tablet (various doses)
Time to Effect
2-4 weeks
Treatment Duration
Long-term, often lifelong
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$800
Monitoring:$50
Side Effect Mgmt:$20
Total Annual:$870
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$1,242.86
Prescription Access Economics
Annual Societal Loss per Patient
$735
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$120/year
Time Cost
$45/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$800/year
Potential OTC Price
$250/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWVaginal Estrogen (Topical) Outcomes
for Genital Prolapse
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+70%
Common Side Effects
Vaginal discharge/irritation
+7%
Breast tenderness
+3%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov