Omeprazole (Proton Pump Inhibitor)
Treatment for Gerd
Typical Dosage: 20-40 mg daily
Effectiveness
80%
Safety Score
68%
Clinical Trials
52
Participants
200K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
20-40 mg daily
Time to Effect
1-2 hours for acid suppression, 1-2 weeks for full symptom relief
Treatment Duration
4-8 weeks for acute, often lifetime for maintenance
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
500(Treat 500 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$230
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$8,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$306.67
Cost per Remission
$383.33
Omeprazole (Proton Pump Inhibitor) Outcomes
for Gerd
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+75%
Remission Rate
+60%
Common Side Effects
Headache
+7%
Diarrhea
+5%
Abdominal pain
+5%
Nausea
+4%
Constipation
+2%
Increased risk of C. difficile infection (long-term)
+0.1%
Bone fractures (long-term)
+0.5%
Sources:
Active Clinical Trials
3 active trials recruiting for Omeprazole (Proton Pump Inhibitor) in Gerd
A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks
NCT06953986RECRUITINGNA
414 participants
INTERVENTIONAL
Hyderabad, India
Started: Jun 7, 2025
Treatment of Gastroesophageal Reflux Disease in Infants
NCT06255886RECRUITINGPHASE4
96 participants
INTERVENTIONAL
Aabenraa, Denmark +2 more
Started: Oct 27, 2025
GERD Infant Feeding Therapeutics Trial (GIFT Trial)
NCT06114836RECRUITINGNA
369 participants
INTERVENTIONAL
Columbus, United States
Started: Mar 14, 2024
Completed Clinical Trials
12 completed trials for Omeprazole (Proton Pump Inhibitor) in Gerd
Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor
NCT03793556COMPLETEDNA
72 participants
INTERVENTIONAL
Rozzano, Italy
Started: May 5, 2017
Prevalence and Predictors of Proton Pump Inhibitor Partial Response in Gastroesophageal Reflux Disease in Systemic Sclerosis
NCT03561233COMPLETEDPHASE1
250 participants
INTERVENTIONAL
Started: May 1, 2013
Study of Acid Reflux in Asthma
NCT00069823COMPLETEDPHASE3
403 participants
INTERVENTIONAL
Birmingham, United States +19 more
Started: Sep 1, 2003
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
NCT00182260COMPLETEDNA
216 participants
INTERVENTIONAL
Hamilton, Canada
Started: Jan 1, 2000
The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease
NCT02505945COMPLETEDPHASE4
152 participants
INTERVENTIONAL
Mobile, United States +20 more
Started: Jun 1, 2015
PPI Test in GP Patients
NCT00318084COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Utrecht, Netherlands
Started: Jan 1, 2003
Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy
NCT00170001COMPLETEDNA
500 participants
INTERVENTIONAL
Rochester, United States
Started: Apr 1, 2005
Implementation of PPI Medication PGX Testing
NCT02794844COMPLETEDPHASE4
28 participants
INTERVENTIONAL
Orlando, United States
Started: Jul 21, 2016
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
NCT01710800COMPLETEDNA
41 participants
INTERVENTIONAL
Started: Sep 1, 2008
A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI)
NCT00734097COMPLETEDPHASE4
314 participants
INTERVENTIONAL
Buenos Aires, Argentina +9 more
Started: Nov 1, 2007
Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study
NCT02081404COMPLETEDNA
98 participants
INTERVENTIONAL
Kansas City, United States +1 more
Started: Mar 1, 2009
Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease
NCT02685150COMPLETEDNA
157 participants
INTERVENTIONAL
Beijing, China
Started: Jan 1, 2016
Showing 20 of 53 total trials