Brimonidine
Treatment for Glaucoma
Typical Dosage: One drop in affected eye(s) 2-3 times daily (0.1%, 0.15%, or 0.2%)
Effectiveness
75%
Safety Score
65%
Clinical Trials
105
Participants
70K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
One drop in affected eye(s) 2-3 times daily (0.1%, 0.15%, or 0.2%)
Time to Effect
1 hour (maximal 2-8 hours)
Treatment Duration
Lifetime
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$480
Monitoring:$600
Side Effect Mgmt:$100
Total Annual:$1,180
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$40,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$1,815
Active Clinical Trials
2 active trials recruiting for Brimonidine in Glaucoma
Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma
NCT07209410RECRUITINGPHASE4
35 participants
INTERVENTIONAL
Kansas City, United States
Started: Nov 1, 2025
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients
NCT04007276NOT YET RECRUITINGPHASE4
60 participants
INTERVENTIONAL
New Orleans, United States
Started: Nov 10, 2026
Completed Clinical Trials
15 completed trials for Brimonidine in Glaucoma
Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma
NCT01105065COMPLETEDNA
46 participants
INTERVENTIONAL
Boston, United States
Started: Mar 1, 2010
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
NCT06449352COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Austin, United States +3 more
Started: Jun 13, 2024
Brimonidine Purite 0.15% Versus Dorzolamide 2% Used as Adjunctive Therapy to Latanoprost
NCT00348400COMPLETEDPHASE4
INTERVENTIONAL
Pittsburgh, United States
Brimonidine vs ALTP in Progressing Human Glaucoma
NCT00466479COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Parma, Italy
Started: Aug 1, 1999
Safety and Efficacy of Brimonidine in Patients With Glaucoma or Ocular Hypertension
NCT00168363COMPLETEDPHASE3
207 participants
INTERVENTIONAL
Started: Jan 1, 2005
Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
NCT03323164COMPLETEDPHASE4
35 participants
INTERVENTIONAL
Philadelphia, United States
Started: Jul 10, 2017
Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma
NCT00317577COMPLETEDPHASE2
160 participants
INTERVENTIONAL
Little Rock, United States +11 more
Started: Dec 1, 1998
Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate
NCT06730516COMPLETEDEARLY_PHASE1
56 participants
INTERVENTIONAL
Zagazig, Egypt
Started: Jun 24, 2024
A Study of 0.15% Brimonidine Tartrate in Patients With Primary Open Angle Glaucoma and Ocular Hypertension
NCT02003534COMPLETEDPHASE4
376 participants
INTERVENTIONAL
Shanghai, China
Started: Jul 1, 2010
Study to Determine if Taking OTC Non-Steroidal Anti-Inflammatory Affects Eye Pressure in Patients Using Glaucoma Drops
NCT00402493COMPLETEDNA
51 participants
INTERVENTIONAL
Willingboro, United States +2 more
Started: Dec 1, 2006
Safety and Effects of Brimonidine Intravitreal Implant in Patients With Glaucomatous Optic Neuropathy
NCT00693485COMPLETEDPHASE2
70 participants
INTERVENTIONAL
Artesia, United States +1 more
Started: Sep 1, 2008
Evaluation of Safety and Efficacy of PDP-716
NCT03450629COMPLETEDPHASE3
682 participants
INTERVENTIONAL
Chandler, United States +46 more
Started: Sep 13, 2018
Earlier Intraocular Pressure Control After Ahmed Glaucoma Valve Implantation for Glaucoma
NCT00869141COMPLETEDPHASE4
52 participants
INTERVENTIONAL
Los Angeles, United States
Started: Mar 1, 2009
Safety and Efficacy Study of Brimonidine in Patients With Glaucoma or Ocular Hypertension
NCT00652483COMPLETEDPHASE3
433 participants
INTERVENTIONAL
Atlanta, United States
Started: May 1, 2003
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
NCT00121147COMPLETEDNA
200 participants
INTERVENTIONAL
Los Angeles, United States +20 more
Started: Sep 1, 2003
Showing 20 of 105 total trials