Latanoprost
Treatment for Glaucoma
Typical Dosage: One drop in affected eye(s) once daily in the evening
Effectiveness
88%
Safety Score
75%
Clinical Trials
251
Participants
200K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
One drop in affected eye(s) once daily in the evening
Time to Effect
3-4 hours (maximal 8-12 hours)
Treatment Duration
Lifetime
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$360
Monitoring:$600
Side Effect Mgmt:$50
Total Annual:$1,010
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$1,188
Comparison vs Timolol
Cost Difference
+$100/year
More expensive
QALY Difference
+0.10 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Prescription Access Economics
Annual Societal Loss per Patient
$800
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$360/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$240/year
Prior auth, claims
Rx Price
$360/year
Potential OTC Price
$180/year
Estimated if OTC available
Early Treatment Benefit
+0.10 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATERequires Monitoring
YesNeeds lab work/checkups
Latanoprost Outcomes
for Glaucoma
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Common Side Effects
Eyelash growth (hypertrichosis)
+30%
Iris pigmentation change
+10%
Conjunctival hyperemia
+8%
Ocular pruritus (itching)
+4%
Burning/stinging upon instillation
+4%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
11 completed trials for Latanoprost in Glaucoma
POLAT-001 Compared to Latanoprost Ophthalmic Solution in Patients With Ocular Hypertension and Open-angle Glaucoma
NCT02466399COMPLETEDPHASE2
80 participants
INTERVENTIONAL
Goose Creek, United States
Started: Jul 1, 2015
Additive Intra-ocular Pressure Reduction Effect of Fixed Combination of Maleate Timolol 0.5%/Dorzolamide 2% on Monotherapy With Latanoprost in Patients With Elevated Intra-ocular Pressure
NCT00906594COMPLETEDPHASE4
56 participants
INTERVENTIONAL
São Paulo, Brazil
Started: Sep 1, 2007
A 6 Month Study Comparing Latanoprost With Timolol in Patients With Open Angle Glaucoma or Ocular Hypertension
NCT00751127COMPLETEDPHASE3
268 participants
INTERVENTIONAL
La Jolla, United States +16 more
Started: Jan 1, 1993
Effect of Age on Latanoprost 0.005% in Patients With Glaucoma
NCT00224289COMPLETEDPHASE4
17 participants
INTERVENTIONAL
New Haven, United States
Started: Mar 1, 2005
A Phase 3 Prospective, Randomized, Double-Masked, 12-Week, Parallel Group Study In Pediatric Subjects With Glaucoma.
NCT00716859COMPLETEDPHASE3
139 participants
INTERVENTIONAL
Pembroke Pines, United States +47 more
Started: Jul 1, 2008
A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.
NCT00638742COMPLETEDPHASE1
47 participants
INTERVENTIONAL
Artesia, United States +12 more
Started: May 1, 2008
Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate
NCT06730516COMPLETEDEARLY_PHASE1
56 participants
INTERVENTIONAL
Zagazig, Egypt
Started: Jun 24, 2024
Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma
NCT01527682COMPLETEDPHASE2
37 participants
INTERVENTIONAL
Brescia, Italy +1 more
Started: Jul 1, 2009
Safety and Efficacy of Punctum Plug Delivery System in Subjects With Open-Angle Glaucoma or Ocular Hypertension
NCT00650702COMPLETEDPHASE2
36 participants
INTERVENTIONAL
Artesia, United States +7 more
Started: Mar 1, 2008
A Study of Open Angle Glaucoma or Ocular Hypertension in Patients Within Scandinavia
NCT00751062COMPLETEDPHASE3
267 participants
INTERVENTIONAL
Hellerup, Denmark +12 more
Started: Nov 1, 1992
A Study of Open Angle Glaucoma or Ocular Hypertension in Patients Within the United Kingdom
NCT00751049COMPLETEDPHASE3
294 participants
INTERVENTIONAL
Aberdeen, United Kingdom +11 more
Started: Dec 1, 1992
Showing 20 of 253 total trials