Azithromycin
Treatment for Gonorrhea
Typical Dosage: 1g or 2g orally single dose (2g with Gentamicin)
Effectiveness
93%
Safety Score
70%
Clinical Trials
18
Participants
70K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
1g or 2g orally single dose (2g with Gentamicin)
Time to Effect
Rapid
Treatment Duration
Single oral dose
Evidence Quality
HIGHNumber Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$40
Monitoring:$300
Side Effect Mgmt:$5
Total Annual:$345
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$370.97
Cost per Remission
$370.97
Prescription Access Economics
Annual Societal Loss per Patient
$350
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$40/year
Potential OTC Price
$70/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEAzithromycin Outcomes
for Gonorrhea
Efficacy Outcomes
Overall Effectiveness
+93%
Response Rate
+93%
Remission Rate
+93%
Common Side Effects
Nausea, vomiting, diarrhea, abdominal pain
+10%
Headache
+2%
QT prolongation
+0.1%
Active Clinical Trials
1 active trial recruiting for Azithromycin in Gonorrhea
Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM
NCT06468462RECRUITINGPHASE4
2.9K participants
INTERVENTIONAL
Kisumu, Kenya +2 more
Started: Oct 29, 2025
Completed Clinical Trials
14 completed trials for Azithromycin in Gonorrhea
Cefixime / Azithromycin pK Study
NCT02708992COMPLETEDPHASE1
10 participants
INTERVENTIONAL
Durham, United States
Started: Apr 28, 2016
Efficacy of Combination Therapies for Gonorrhea Treatment
NCT00926796COMPLETEDPHASE4
614 participants
INTERVENTIONAL
Birmingham, United States +4 more
Started: Jun 1, 2010
Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
NCT06090565COMPLETEDPHASE4
161 participants
INTERVENTIONAL
Prague, Czechia +1 more
Started: Apr 1, 2021
A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea
NCT04010539COMPLETEDPHASE3
628 participants
INTERVENTIONAL
Los Angeles, United States +50 more
Started: Oct 21, 2019
Zoliflodacin in Uncomplicated Gonorrhoea
NCT03959527COMPLETEDPHASE3
1.01K participants
INTERVENTIONAL
Birmingham, United States +16 more
Started: Nov 6, 2019
Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea
NCT02210325COMPLETEDPHASE3
264 participants
INTERVENTIONAL
Baltimore, United States +4 more
Started: Aug 1, 2014
The Pharmacokinetics of Extended Duration High-dose Cefixime for the Decreased Susceptibility of Neisseria Gonorrhoeae: A Phase I Pilot Study
NCT01949363COMPLETEDPHASE1
25 participants
INTERVENTIONAL
Baltimore, United States
Started: Dec 1, 2013
Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)
NCT04870138COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Mar 10, 2013
Trial Comparing Ceftriaxone Plus Azithromycin Versus Ceftriaxone for the Treatment of Gonorrhea
NCT05027516COMPLETEDPHASE4
42 participants
INTERVENTIONAL
Antwerp, Belgium
Started: Jan 17, 2022
Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers
NCT01329588COMPLETEDPHASE4
636 participants
INTERVENTIONAL
Cotonou, Benin
Started: Mar 1, 2001
Expedited Partner Therapy for MSM in Peru
NCT01720654COMPLETEDNA
165 participants
INTERVENTIONAL
Lima, Peru
Started: Aug 1, 2012
NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
NCT00322465COMPLETEDPHASE2
305 participants
INTERVENTIONAL
Birmingham, United States +3 more
Started: Nov 1, 2006
Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China
NCT00644150COMPLETEDNA
1.37K participants
INTERVENTIONAL
Hefei, China
Started: Apr 1, 2007
Washington State Community Expedited Partner Treatment (EPT) Trial
NCT01665690COMPLETEDPHASE4
33.2K participants
INTERVENTIONAL
Olympia, United States +1 more
Started: Jul 1, 2007