Cefixime
Treatment for Gonorrhea
Typical Dosage: 800 mg orally single dose
Effectiveness
88%
Safety Score
70%
Clinical Trials
10
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
800 mg orally single dose
Time to Effect
Rapid
Treatment Duration
Single oral dose
Evidence Quality
MODERATENumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$45
Monitoring:$350
Side Effect Mgmt:$5
Total Annual:$400
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
0.04
Outcome-Based Costs
Cost per Responder
$454.55
Cost per Remission
$454.55
Prescription Access Economics
Annual Societal Loss per Patient
$355
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$45/year
Potential OTC Price
$70/year
Estimated if OTC available
Early Treatment Benefit
+0.04 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATECefixime Outcomes
for Gonorrhea
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+88%
Remission Rate
+88%
Common Side Effects
Diarrhea
+10%
Nausea
+5%
Abdominal pain
+5%
Headache
+2%
Sources:
Active Clinical Trials
2 active trials recruiting for Cefixime in Gonorrhea
Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae
NCT05294588RECRUITINGPHASE2
140 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Apr 18, 2022
Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM
NCT06468462RECRUITINGPHASE4
2.9K participants
INTERVENTIONAL
Kisumu, Kenya +2 more
Started: Oct 29, 2025
Completed Clinical Trials
7 completed trials for Cefixime in Gonorrhea
The Pharmacokinetics of Extended Duration High-dose Cefixime for the Decreased Susceptibility of Neisseria Gonorrhoeae: A Phase I Pilot Study
NCT01949363COMPLETEDPHASE1
25 participants
INTERVENTIONAL
Baltimore, United States
Started: Dec 1, 2013
Cefixime / Azithromycin pK Study
NCT02708992COMPLETEDPHASE1
10 participants
INTERVENTIONAL
Durham, United States
Started: Apr 28, 2016
Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
NCT06090565COMPLETEDPHASE4
161 participants
INTERVENTIONAL
Prague, Czechia +1 more
Started: Apr 1, 2021
Experimental Human Infection With Neisseria Gonorrhoeae
NCT03840811COMPLETEDPHASE1
27 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Apr 23, 2017
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT05216744COMPLETEDPHASE2
125 participants
INTERVENTIONAL
Haiphong, Vietnam
Started: Jul 15, 2021
Expedited Partner Therapy for MSM in Peru
NCT01720654COMPLETEDNA
165 participants
INTERVENTIONAL
Lima, Peru
Started: Aug 1, 2012
Washington State Community Expedited Partner Treatment (EPT) Trial
NCT01665690COMPLETEDPHASE4
33.2K participants
INTERVENTIONAL
Olympia, United States +1 more
Started: Jul 1, 2007