Ceftriaxone
Treatment for Gonorrhea
Typical Dosage: 500 mg IM single dose
Effectiveness
98%
Safety Score
70%
Clinical Trials
17
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
500 mg IM single dose
Time to Effect
24-48 hours
Treatment Duration
Single IM dose
Evidence Quality
HIGHNumber Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Confidence Score
98%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$300
Side Effect Mgmt:$10
Total Annual:$330
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$336.73
Cost per Remission
$336.73
Prescription Access Economics
Annual Societal Loss per Patient
$350
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$20/year
Potential OTC Price
$50/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATECeftriaxone Outcomes
for Gonorrhea
Efficacy Outcomes
Overall Effectiveness
+98%
Response Rate
+98%
Remission Rate
+98%
Common Side Effects
Injection site pain
+15%
Diarrhea
+7%
Nausea/Vomiting
+2%
Rash
+1%
Headache
+1%
Sources:
Active Clinical Trials
2 active trials recruiting for Ceftriaxone in Gonorrhea
500-mg Versus 1000-mg Ceftriaxone for Uncomplicated Gonorrhea Infection
NCT07710118RECRUITINGPHASE3
400 participants
INTERVENTIONAL
Taipei, Taiwan
Started: Jul 1, 2026
Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections
NCT07631364NOT YET RECRUITINGPHASE3
360 participants
INTERVENTIONAL
Paris, France
Started: Sep 1, 2026
Completed Clinical Trials
14 completed trials for Ceftriaxone in Gonorrhea
Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
NCT06090565COMPLETEDPHASE4
161 participants
INTERVENTIONAL
Prague, Czechia +1 more
Started: Apr 1, 2021
Randomized, Open-label Phase 2 Study of Oral AZD0914 in the Treatment of Gonorrhea
NCT02257918COMPLETEDPHASE2
180 participants
INTERVENTIONAL
Birmingham, United States +4 more
Started: Nov 25, 2014
A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea
NCT04010539COMPLETEDPHASE3
628 participants
INTERVENTIONAL
Los Angeles, United States +50 more
Started: Oct 21, 2019
Zoliflodacin in Uncomplicated Gonorrhoea
NCT03959527COMPLETEDPHASE3
1.01K participants
INTERVENTIONAL
Birmingham, United States +16 more
Started: Nov 6, 2019
A Study Evaluating Efficacy and Safety of CRO-SBT in the Treatment of Gonorrhea
NCT04202068COMPLETEDPHASE4
113 participants
INTERVENTIONAL
Started: Jul 3, 2015
Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea
NCT02210325COMPLETEDPHASE3
264 participants
INTERVENTIONAL
Baltimore, United States +4 more
Started: Aug 1, 2014
Trial Comparing Ceftriaxone Plus Azithromycin Versus Ceftriaxone for the Treatment of Gonorrhea
NCT05027516COMPLETEDPHASE4
42 participants
INTERVENTIONAL
Antwerp, Belgium
Started: Jan 17, 2022
Response Rate to Ceftriaxone 1g IM in Gonorrhoea : a French Retrospective Monocentric Study
NCT04902560COMPLETED
120 participants
OBSERVATIONAL
Montpellier, France
Started: May 1, 2021
New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea
NCT03294395COMPLETEDPHASE3
346 participants
INTERVENTIONAL
Amsterdam, Netherlands
Started: Sep 18, 2017
Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)
NCT04870138COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Mar 10, 2013
Experimental Human Infection With Neisseria Gonorrhoeae
NCT03840811COMPLETEDPHASE1
27 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Apr 23, 2017
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT05216744COMPLETEDPHASE2
125 participants
INTERVENTIONAL
Haiphong, Vietnam
Started: Jul 15, 2021
Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae
NCT05294588COMPLETEDPHASE2
65 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Apr 18, 2022
Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China
NCT00644150COMPLETEDNA
1.37K participants
INTERVENTIONAL
Hefei, China
Started: Apr 1, 2007