Doxycycline
Treatment for Gonorrhea
Typical Dosage: 100 mg orally twice daily for 7 days
Effectiveness
95%
Safety Score
70%
Clinical Trials
9
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
100 mg orally twice daily for 7 days
Time to Effect
Days
Treatment Duration
7 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$300
Side Effect Mgmt:$5
Total Annual:$320
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$336.84
Cost per Remission
$336.84
Prescription Access Economics
Annual Societal Loss per Patient
$355
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$15/year
Potential OTC Price
$40/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEDoxycycline Outcomes
for Gonorrhea
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
GI upset (nausea, vomiting, diarrhea)
+15%
Photosensitivity
+10%
Esophageal irritation/ulceration
+1%
Vaginal candidiasis
+5%
Active Clinical Trials
3 active trials recruiting for Doxycycline in Gonorrhea
Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
NCT06188442RECRUITINGPHASE4
300 participants
INTERVENTIONAL
Shatin, Hong Kong
Started: Mar 29, 2025
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
NCT06738407NOT YET RECRUITINGPHASE4
760 participants
INTERVENTIONAL
Los Angeles, United States +11 more
Started: Jan 5, 2026
Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM
NCT06468462RECRUITINGPHASE4
2.9K participants
INTERVENTIONAL
Kisumu, Kenya +2 more
Started: Oct 29, 2025
Completed Clinical Trials
5 completed trials for Doxycycline in Gonorrhea
Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
NCT06090565COMPLETEDPHASE4
161 participants
INTERVENTIONAL
Prague, Czechia +1 more
Started: Apr 1, 2021
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
NCT03980223COMPLETEDPHASE4
641 participants
INTERVENTIONAL
San Francisco, United States +2 more
Started: Nov 26, 2019
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT05216744COMPLETEDPHASE2
125 participants
INTERVENTIONAL
Haiphong, Vietnam
Started: Jul 15, 2021
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
NCT04050540COMPLETEDPHASE4
449 participants
INTERVENTIONAL
Kisumu, Kenya
Started: Feb 5, 2020
NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
NCT00322465COMPLETEDPHASE2
305 participants
INTERVENTIONAL
Birmingham, United States +3 more
Started: Nov 1, 2006