NSAIDs (e.g., Indomethacin, Naproxen)
Treatment for Gout
Typical Dosage: Indomethacin 25-50 mg TID; Naproxen 750 mg initial, then 250 mg Q8hr
Effectiveness
88%
Safety Score
75%
Clinical Trials
150
Participants
15K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
Indomethacin 25-50 mg TID; Naproxen 750 mg initial, then 250 mg Q8hr
Time to Effect
1-2 hours
Treatment Duration
5-10 days (per flare)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$150
Side Effect Mgmt:$10
Total Annual:$190
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.007
Outcome-Based Costs
Cost per Responder
$211
NSAIDs (e.g., Indomethacin, Naproxen) Outcomes
for Gout
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+90%
Common Side Effects
GI upset (nausea, dyspepsia)
+15%
Fluid retention, edema
+7%
Increased blood pressure
+3%
GI bleeding/ulcer (serious)
+0.5%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov