Loop Diuretics (Furosemide)
Treatment for Heart Failure
Typical Dosage: 20-80 mg daily or BID
Effectiveness
65%
Safety Score
65%
Clinical Trials
44
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
20-80 mg daily or BID
Time to Effect
immediate
Treatment Duration
lifetime (as needed)
Evidence Quality
MODERATEConfidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$800
Side Effect Mgmt:$150
Total Annual:$1,050
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$1,400
Comparison vs No symptomatic treatment
Cost Difference
$-800/year
Less expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Loop Diuretics (Furosemide) Outcomes
for Heart Failure
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+75%
Common Side Effects
Electrolyte imbalance (hypokalemia, hyponatremia)
+15%
Dehydration/Hypotension
+8%
Dizziness
+7%
Sources:
Active Clinical Trials
2 active trials recruiting for Loop Diuretics (Furosemide) in Heart Failure
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
NCT02638142RECRUITING
370 participants
OBSERVATIONAL
Chioggia, Italy +3 more
Started: Dec 1, 2015
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
NCT06414759RECRUITINGPHASE4
110 participants
INTERVENTIONAL
Giza, Egypt
Started: Jul 1, 2024
Completed Clinical Trials
8 completed trials for Loop Diuretics (Furosemide) in Heart Failure
Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion
NCT03592836COMPLETEDPHASE3
80 participants
INTERVENTIONAL
Torino, Italy
Started: May 1, 2013
Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)
NCT00577135COMPLETEDPHASE3
308 participants
INTERVENTIONAL
Atlanta, United States +8 more
Started: Feb 1, 2008
Loop Diuretics Administration and Acute Heart Failure
NCT01441245COMPLETEDPHASE4
57 participants
INTERVENTIONAL
Siena, Italy
Started: Apr 1, 2010
TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
NCT03296813COMPLETEDPHASE3
2.97K participants
INTERVENTIONAL
Alexander City, United States +59 more
Started: Jul 11, 2018
OUTpatient Intravenous LASix Trial in Reducing Hospitalization for Acute Decompensated Heart Failure
NCT04691687COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Started: May 1, 2012
An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic
NCT03730961COMPLETEDPHASE2
23 participants
INTERVENTIONAL
Glasgow, United Kingdom +1 more
Started: Jan 17, 2019
Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure
NCT00355667COMPLETEDPHASE4
320 participants
INTERVENTIONAL
Nishinomiya, Japan
Started: Jun 1, 2006
Loop Diuretic Dosage in Patients With Acute Heart Failure and Renal Failure: Conventional Versus Carbohydrate Antigen 125-guided Therapy (IMPROVE-HF)
NCT02643147COMPLETEDPHASE4
170 participants
INTERVENTIONAL
Valencia, Spain
Started: Jan 1, 2015
Showing 20 of 45 total trials