Micronized Purified Flavonoid Fraction (MPFF)
Treatment for Hemorrhoids
Typical Dosage: Acute: 1000mg TID for 4 days, then 1000mg BID for 3 days. Chronic: 500-1000mg daily.
Effectiveness
68%
Safety Score
85%
Clinical Trials
2
Participants
7.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
85
DangerousModerateSafe
Treatment Details
Dosage Range
Acute: 1000mg TID for 4 days, then 1000mg BID for 3 days. Chronic: 500-1000mg daily.
Time to Effect
Days to 1 week
Treatment Duration
Acute episodes (7 days), chronic management (weeks to months)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$50
Side Effect Mgmt:$25
Total Annual:$475
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$4,750/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$731
Micronized Purified Flavonoid Fraction (MPFF) Outcomes
for Hemorrhoids
Efficacy Outcomes
Overall Effectiveness
+68%
Response Rate
+65%
Common Side Effects
Gastrointestinal disturbances (diarrhea, nausea)
+3%
Headache
+1%
Active Clinical Trials
2 active trials recruiting for Micronized Purified Flavonoid Fraction (MPFF) in Hemorrhoids
The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study
NCT06748014ENROLLING BY INVITATIONEARLY_PHASE1
120 participants
INTERVENTIONAL
Chiang Mai, Thailand
Started: Dec 20, 2024
The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial
NCT06363513NOT YET RECRUITINGNA
60 participants
INTERVENTIONAL
Chiang Mai, Thailand
Started: Apr 1, 2024