Liposomal Doxorubicin
Treatment for Hepatoblastoma
Typical Dosage: Various regimens, e.g., 20-30 mg/m2 per cycle
Effectiveness
70%
Safety Score
28%
Clinical Trials
6
Participants
2K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
28
DangerousModerateSafe
Treatment Details
Dosage Range
Various regimens, e.g., 20-30 mg/m2 per cycle
Time to Effect
weeks
Treatment Duration
Part of a 4-6 month regimen
Evidence Quality
MODERATEConfidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15,000
Monitoring:$5,000
Side Effect Mgmt:$10,000
Total Annual:$30,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
15.5
Outcome-Based Costs
Cost per Responder
$42,857.14
Cost per Remission
$42,857.14
Comparison vs Conventional Doxorubicin
Cost Difference
+$13,000/year
More expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
No dominance
Liposomal Doxorubicin Outcomes
for Hepatoblastoma
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Remission Rate
+70%
Common Side Effects
Myelosuppression
+75%
Hand-foot syndrome
+35%
Nausea and vomiting
+70%
Mucositis
+45%
Cardiotoxicity (reduced)
+10%
Sources:
Active Clinical Trials
4 active trials recruiting for Liposomal Doxorubicin in Hepatoblastoma
A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy
NCT04478292RECRUITINGPHASE3
330 participants
INTERVENTIONAL
Shanghai, China
Started: Mar 1, 2021
Paediatric Hepatic International Tumour Trial
NCT03017326ACTIVE NOT RECRUITINGPHASE3
450 participants
INTERVENTIONAL
Vienna, Austria +31 more
Started: Aug 24, 2017
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer
NCT00980460ACTIVE NOT RECRUITINGPHASE3
236 participants
INTERVENTIONAL
Birmingham, United States +208 more
Started: Sep 14, 2009
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
NCT03533582ACTIVE NOT RECRUITINGPHASE3
537 participants
INTERVENTIONAL
Birmingham, United States +204 more
Started: May 24, 2018
Completed Clinical Trials
1 completed trial for Liposomal Doxorubicin in Hepatoblastoma
Chemotherapy in Treating Children With Liver Cancer
NCT00003912COMPLETEDPHASE3
260 participants
INTERVENTIONAL
Padua, Italy
Started: Jun 1, 1998