Vincristine + 5-Fluorouracil (5-FU)
Treatment for Hepatoblastoma
Typical Dosage: Vincristine 1.5-2 mg/m2; 5-FU 500 mg/m2
Effectiveness
60%
Safety Score
30%
Clinical Trials
5
Participants
3K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
Vincristine 1.5-2 mg/m2; 5-FU 500 mg/m2
Time to Effect
weeks
Treatment Duration
Variable, often in specific protocols
Evidence Quality
MODERATEConfidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,000
Monitoring:$5,000
Side Effect Mgmt:$7,000
Total Annual:$13,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
8
Outcome-Based Costs
Cost per Responder
$32,500
Cost per Remission
$32,500
Vincristine + 5-Fluorouracil (5-FU) Outcomes
for Hepatoblastoma
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+40%
Remission Rate
+40%
Common Side Effects
Peripheral neuropathy (Vincristine)
+60%
Myelosuppression (5-FU)
+60%
Mucositis (5-FU)
+45%
Constipation (Vincristine)
+40%
Diarrhea (5-FU)
+40%
Active Clinical Trials
4 active trials recruiting for Vincristine + 5-Fluorouracil (5-FU) in Hepatoblastoma
Paediatric Hepatic International Tumour Trial
NCT03017326ACTIVE NOT RECRUITINGPHASE3
450 participants
INTERVENTIONAL
Vienna, Austria +31 more
Started: Aug 24, 2017
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer
NCT00980460ACTIVE NOT RECRUITINGPHASE3
236 participants
INTERVENTIONAL
Birmingham, United States +208 more
Started: Sep 14, 2009
A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy
NCT04478292RECRUITINGPHASE3
330 participants
INTERVENTIONAL
Shanghai, China
Started: Mar 1, 2021
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
NCT03533582ACTIVE NOT RECRUITINGPHASE3
537 participants
INTERVENTIONAL
Birmingham, United States +204 more
Started: May 24, 2018
Completed Clinical Trials
1 completed trial for Vincristine + 5-Fluorouracil (5-FU) in Hepatoblastoma
Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer
NCT00003994COMPLETEDPHASE3
277 participants
INTERVENTIONAL
Arcadia, United States
Started: Mar 1, 1999