Amlodipine
Treatment for Hypertension
Typical Dosage: 2.5-10mg daily
Effectiveness
87%
Safety Score
70%
Clinical Trials
540
Participants
400K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
2.5-10mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
40(Treat 40 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$100
Side Effect Mgmt:$50
Total Annual:$170
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$8,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$283
Comparison vs No treatment
Cost Difference
$-170/year
Less expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Amlodipine Outcomes
for Hypertension
Efficacy Outcomes
Overall Effectiveness
+87%
Response Rate
+60%
Common Side Effects
Peripheral edema
+15%
Headache
+10%
Flushing
+5%
Dizziness
+3%
Active Clinical Trials
1 active trial recruiting for Amlodipine in Hypertension
Morning Versus Bedtime Dosing of Antihypertensive Medication
NCT05089448RECRUITINGPHASE4
300 participants
INTERVENTIONAL
Shanghai, China
Started: Jan 28, 2021
Completed Clinical Trials
14 completed trials for Amlodipine in Hypertension
Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)
NCT00446524COMPLETEDPHASE3
403 participants
INTERVENTIONAL
Fukuoka, Japan
Started: Feb 1, 2007
Candesartan Cilexetil/Amlodipine Besilate Combination Tablets LD, HD Special Drug Use Surveillance "Hypertension: Long-Term Use"
NCT02068495COMPLETED
3.41K participants
OBSERVATIONAL
Started: Jun 15, 2010
Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension
NCT01131546COMPLETEDPHASE4
1.08K participants
INTERVENTIONAL
Beijing, China
Started: Dec 1, 2009
INTERVENCION Trial
NCT02373163COMPLETEDPHASE4
166 participants
INTERVENTIONAL
Arequipa, Peru
Started: Sep 1, 2014
Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Stage 2 Hypertension
NCT01127217COMPLETEDPHASE3
149 participants
INTERVENTIONAL
Seoul, South Korea
Started: May 1, 2009
A Comparative Study Between Amlodipine 10mg And 5mg With Hypertension For Whom 5mg Is Insufficient
NCT00415623COMPLETEDPHASE3
305 participants
INTERVENTIONAL
Kasuya-gun, Japan +13 more
Started: Jan 1, 2007
Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation
NCT02353806COMPLETEDPHASE4
16 participants
INTERVENTIONAL
Dallas, United States
Started: Jan 1, 2015
Bioavailability of 5 mg of Levamlodipine Maleate Tablets Versus 10 mg of Amlodipine Besylate Tablet in Healthy Subjects
NCT03657550COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Long Beach, United States
Started: May 31, 2018
Efficacy and Safety of Aliskiren Administered in Combination With Amlodipine Versus Amlodipine Alone in African American Patients With Stage 2 Hypertension
NCT00853957COMPLETEDPHASE4
443 participants
INTERVENTIONAL
Chicago, United States +8 more
Started: Feb 1, 2009
Irbesartan/Amlodipine in Hypertensive Patients Uncontrolled on Amlodipine 5 mg Monotherapy
NCT00956644COMPLETEDPHASE3
406 participants
INTERVENTIONAL
Campinas, Brazil +39 more
Started: Jul 1, 2009
Amlodipine 10mg Drug Use Investigation
NCT01252563COMPLETED
14.1K participants
OBSERVATIONAL
Started: Dec 1, 2010
Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Essential Hypertension
NCT00940667COMPLETEDPHASE3
185 participants
INTERVENTIONAL
Seoul, Busan, Etc., South Korea
Started: May 1, 2008
N-of-1 Trials for Blood Pressure Medications in Adults
NCT02744456COMPLETEDEARLY_PHASE1
10 participants
INTERVENTIONAL
New York, United States
Started: Aug 1, 2014
Perindopril Amlodipine for the Treatment of Hypertension
NCT01556997COMPLETEDPHASE3
837 participants
INTERVENTIONAL
Huntsville, United States +47 more
Started: Feb 1, 2012
Showing 20 of 545 total trials