Chlorthalidone
Treatment for Hypertension
Typical Dosage: 12.5-25mg daily
Effectiveness
90%
Safety Score
70%
Clinical Trials
89
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
12.5-25mg daily
Time to Effect
1-3 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
30(Treat 30 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$220
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$367
Comparison vs No treatment
Cost Difference
$-220/year
Less expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Chlorthalidone Outcomes
for Hypertension
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+60%
Common Side Effects
Hypokalemia
+10%
Hyperuricemia
+7%
Dizziness/Orthostatic Hypotension
+5%
Hyponatremia
+3%
Active Clinical Trials
1 active trial recruiting for Chlorthalidone in Hypertension
Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.
NCT06287580ENROLLING BY INVITATIONEARLY_PHASE1
50 participants
INTERVENTIONAL
Dallas, United States
Started: Aug 15, 2024
Completed Clinical Trials
11 completed trials for Chlorthalidone in Hypertension
Efficacy and Safety of Azilsartan Medoxomil Co-Administered With Chlorthalidone in Participants With Essential Hypertension
NCT00591773COMPLETEDPHASE3
551 participants
INTERVENTIONAL
Huntsville, United States +45 more
Started: Sep 1, 2007
Pharmacogenomic Evaluation of Antihypertensive Responses 2
NCT01203852COMPLETEDPHASE4
839 participants
INTERVENTIONAL
Gainesville, United States +2 more
Started: Aug 1, 2010
Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension
NCT00847626COMPLETEDPHASE3
1.71K participants
INTERVENTIONAL
Birmingham, United States +98 more
Started: Jan 1, 2009
Hypertension Screening and Treatment Program
NCT00007592COMPLETED
OBSERVATIONAL
Sepulveda, United States +11 more
Started: Jun 1, 1989
Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
NCT02121041COMPLETEDNA
28 participants
INTERVENTIONAL
Chapel Hill, United States
Started: May 1, 2014
Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension
NCT01850160COMPLETEDPHASE3
124 participants
INTERVENTIONAL
Bogota DC, Colombia +7 more
Started: Apr 1, 2013
Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
NCT02152969COMPLETEDPHASE1
66 participants
INTERVENTIONAL
Seoul, South Korea
Started: May 1, 2014
Chlorthalidone in Chronic Kidney Disease
NCT02841280COMPLETEDPHASE2
160 participants
INTERVENTIONAL
Indianapolis, United States
Started: Jul 1, 2016
Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus
NCT02644395COMPLETEDPHASE3
49 participants
INTERVENTIONAL
Rotterdam, Netherlands
Started: Jan 18, 2013
A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD
NCT01750294COMPLETEDPHASE4
14 participants
INTERVENTIONAL
Indianapolis, United States
Started: Aug 1, 2012
Pharmacokinetic Interactions and Safety Study of Telmisartan and Chlorthalidone
NCT01806363COMPLETEDPHASE1
60 participants
INTERVENTIONAL
Daegu, South Korea
Started: Nov 1, 2012
Showing 20 of 90 total trials