Lisinopril
Treatment for Hypertension
Typical Dosage: 10-40mg daily
Effectiveness
88%
Safety Score
70%
Clinical Trials
80
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
10-40mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
35(Treat 35 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$220
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$7,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$367
Comparison vs No treatment
Cost Difference
$-220/year
Less expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Lisinopril Outcomes
for Hypertension
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+60%
Common Side Effects
Cough
+15%
Dizziness/Orthostatic Hypotension
+5%
Hyperkalemia
+3%
Angioedema
+0.1%
Sources:
Active Clinical Trials
1 active trial recruiting for Lisinopril in Hypertension
OptiZ: Real World Evidence Study
NCT06745726NOT YET RECRUITING
113 participants
OBSERVATIONAL
Norwich, United Kingdom
Started: Mar 1, 2025
Completed Clinical Trials
15 completed trials for Lisinopril in Hypertension
Safety Study of Lisinopril in Children and Adolescents With a Kidney Transplant
NCT01491919COMPLETEDPHASE1
26 participants
INTERVENTIONAL
Birmingham, United States +6 more
Started: Jun 1, 2012
Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment
NCT06372470COMPLETED
20 participants
OBSERVATIONAL
Norwich, United Kingdom
Started: Apr 15, 2024
Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure
NCT00624065COMPLETEDPHASE3
348 participants
INTERVENTIONAL
Mobile, United States +75 more
Started: Mar 1, 2008
The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial
NCT00347360COMPLETEDPHASE3
654 participants
INTERVENTIONAL
Anniston, United States +150 more
Started: Jul 1, 2006
The Vascular Effects of Carvedilol Controlled Release (CR) in Abdominally Obese Hypertensive Patients
NCT00459056COMPLETEDPHASE3
25 participants
INTERVENTIONAL
Saint Paul, United States
Started: Apr 1, 2007
Comparison Of Morning And Evening Dosing Of Valsartan And Lisinopril In Patients With Diabetes
NCT00241124COMPLETEDPHASE4
1.1K participants
INTERVENTIONAL
Investigative Centers, Germany
Started: Apr 1, 2004
VALERIA: Valsartan in Combination With Lisinopril in Hypertensive Patients With Microalbuminuria
NCT00171067COMPLETEDPHASE3
134 participants
INTERVENTIONAL
Investigative Centers, Germany +1 more
Started: Jul 1, 2004
Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension
NCT02184858COMPLETEDPHASE4
13 participants
INTERVENTIONAL
Ghent, Belgium
Started: Jun 25, 2014
Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril
NCT01258764COMPLETEDNA
2 participants
INTERVENTIONAL
La Jolla, United States
Started: Nov 1, 2010
A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.
NCT00552708COMPLETEDPHASE1
55 participants
INTERVENTIONAL
Tacoma, United States
Started: Sep 1, 2007
CAndesartan vs LIsinopril Effects on the BRain
NCT01984164COMPLETEDPHASE2
176 participants
INTERVENTIONAL
Atlanta, United States
Started: Aug 20, 2014
Non-invasive Haemodynamic Assessment in Hypertension
NCT01996085COMPLETEDNA
144 participants
INTERVENTIONAL
Warsaw, Poland
Started: Jan 1, 2013
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
NCT02412761COMPLETEDNA
42 participants
INTERVENTIONAL
Houston, United States
Started: Jun 1, 2013
Comparison of Optimal Hypertension Regimens
NCT02847338COMPLETEDPHASE4
940 participants
INTERVENTIONAL
Cambridge, United Kingdom +13 more
Started: Nov 1, 2016
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
NCT02441842COMPLETEDPHASE4
85 participants
INTERVENTIONAL
Started: Mar 1, 2006
Showing 20 of 80 total trials