Methimazole
Treatment for Hyperthyroidism
Typical Dosage: Initial: 10-30 mg daily; Maintenance: 5-15 mg daily
Effectiveness
85%
Safety Score
55%
Clinical Trials
31
Participants
80K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
Initial: 10-30 mg daily; Maintenance: 5-15 mg daily
Time to Effect
1-2 weeks for symptom improvement, 4-8 weeks for hormone normalization
Treatment Duration
12-18 months typically, can be lifelong
Evidence Quality
HIGHNumber Needed to Harm (NNH)
2500(Treat 2500 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$900
Side Effect Mgmt:$100
Total Annual:$1,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$45,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$1,333
Cost per Remission
$2,400
Methimazole Outcomes
for Hyperthyroidism
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+90%
Remission Rate
+50%
Common Side Effects
Rash/itching
+15%
Arthralgia/myalgia
+5%
Nausea/vomiting
+5%
Agranulocytosis
+0.5%
Hepatotoxicity
+0.1%
Active Clinical Trials
4 active trials recruiting for Methimazole in Hyperthyroidism
A Clinical Study of Hyperthyroidism in Children
NCT06570967RECRUITING
1K participants
OBSERVATIONAL
Shenyang, China
Started: Jul 18, 2023
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
NCT05461820RECRUITINGPHASE4
240 participants
INTERVENTIONAL
Nanjing, China
Started: May 1, 2018
A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy
NCT04776993RECRUITINGPHASE3
52 participants
INTERVENTIONAL
Pisa, Italy
Started: Mar 2, 2023
A Clinical Follow-up Study on Drug Therapy for Graves' Disease Patients in China
NCT07040306RECRUITING
1K participants
OBSERVATIONAL
Shenyang, China
Started: Nov 14, 2012
Completed Clinical Trials
10 completed trials for Methimazole in Hyperthyroidism
Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma
NCT04346901COMPLETEDPHASE1
23 participants
INTERVENTIONAL
Jakarta, Indonesia
Started: Aug 1, 2019
The Role of Thyroid Status in Regulating Brown Adipose Tissue Activity, White Adipose Tissue Partitioning and Resting Energy Expenditure
NCT03064542COMPLETED
30 participants
OBSERVATIONAL
Singapore, Singapore
Started: Oct 13, 2015
Hyperthyroidism: Methimazole Plus L-carnitine and Selenium
NCT04946123COMPLETEDNA
60 participants
INTERVENTIONAL
Torino, Italy
Started: Jul 5, 2021
Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
NCT01560299COMPLETEDNA
150 participants
INTERVENTIONAL
Mashhad, Iran
Started: Feb 1, 2010
Treatment of Graves' Hyperthyroidism With Selenium Plus Methimazole
NCT02727738COMPLETEDNA
30 participants
INTERVENTIONAL
Pisa, Italy
Started: Jan 1, 2014
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
NCT05118542COMPLETEDPHASE3
36 participants
INTERVENTIONAL
Jakarta Pusat, Indonesia
Started: Jan 1, 2019
Antithyroid Drugs During Radioiodine Therapy
NCT00150137COMPLETEDPHASE4
80 participants
INTERVENTIONAL
Odense, Denmark
Started: Jan 1, 2003
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
NCT02376088COMPLETED
328 participants
OBSERVATIONAL
Started: Jun 1, 2011
Block-replacement Therapy During Radioiodine Therapy
NCT00150124COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Odense, Denmark
Started: Jan 1, 2003
Iodinated Contrast Media Induced Hyperthyroidism
NCT04304794COMPLETED
36 participants
OBSERVATIONAL
Started: Jan 2, 2015
Showing 20 of 31 total trials