Propranolol
Treatment for Hyperthyroidism
Typical Dosage: 10-40 mg 3-4 times daily
Effectiveness
75%
Safety Score
70%
Clinical Trials
6
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
10-40 mg 3-4 times daily
Time to Effect
Hours to days for symptom control
Treatment Duration
Variable, often weeks-months adjunctively
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$100
Side Effect Mgmt:$50
Total Annual:$250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$10,000/QALY
QALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$294
Prescription Access Economics
Annual Societal Loss per Patient
$160
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$40/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$100/year
Potential OTC Price
$50/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATERequires Monitoring
YesNeeds lab work/checkups
Propranolol Outcomes
for Hyperthyroidism
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+85%
Common Side Effects
Bradycardia
+20%
Fatigue
+15%
Hypotension
+10%
Dizziness
+10%
Bronchospasm (in asthmatics)
+1%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
4 completed trials for Propranolol in Hyperthyroidism
Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol
NCT03393728COMPLETEDPHASE4
10 participants
INTERVENTIONAL
Started: Sep 1, 2008
Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy
NCT03379181COMPLETEDPHASE4
19 participants
INTERVENTIONAL
Basel, Switzerland
Started: Jul 18, 2017
Low Doses of Cholestyramine in the Treatment of Hyperthyroidism
NCT00677469COMPLETEDNA
45 participants
INTERVENTIONAL
Shiraz, Iran
Started: Jul 1, 2007
Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study)
NCT01458600COMPLETEDPHASE4
65 participants
INTERVENTIONAL
Malmo, Sweden +2 more
Started: Sep 1, 2006