Propylthiouracil (PTU)
Treatment for Hyperthyroidism
Typical Dosage: Initial: 100-150 mg 3 times daily; Maintenance: 50 mg 2-3 times daily
Effectiveness
80%
Safety Score
50%
Clinical Trials
2
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
Initial: 100-150 mg 3 times daily; Maintenance: 50 mg 2-3 times daily
Time to Effect
1-2 weeks for symptom improvement, 4-8 weeks for hormone normalization
Treatment Duration
12-18 months typically, can be lifelong
Evidence Quality
HIGHNumber Needed to Harm (NNH)
750(Treat 750 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$1,200
Side Effect Mgmt:$200
Total Annual:$1,800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$55,000/QALY
QALYs Gained
0.9
Outcome-Based Costs
Cost per Responder
$2,118
Cost per Remission
$4,500
Propylthiouracil (PTU) Outcomes
for Hyperthyroidism
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+85%
Remission Rate
+40%
Common Side Effects
Rash/itching
+15%
Arthralgia/myalgia
+5%
Nausea/vomiting
+5%
Agranulocytosis
+0.5%
Severe Hepatotoxicity (can be fatal)
+0.2%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
2 completed trials for Propylthiouracil (PTU) in Hyperthyroidism
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
NCT05118542COMPLETEDPHASE3
36 participants
INTERVENTIONAL
Jakarta Pusat, Indonesia
Started: Jan 1, 2019
Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients
NCT02993302COMPLETEDPHASE2
25 participants
INTERVENTIONAL
Started: Jul 1, 2014