Total Thyroidectomy
Treatment for Hyperthyroidism
Effectiveness
98%
Safety Score
40%
Clinical Trials
12
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Time to Effect
Immediate (days-weeks for hormone normalization)
Treatment Duration
One-time surgery, lifelong levothyroxine
Evidence Quality
HIGHNumber Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$150
Monitoring:$600
Side Effect Mgmt:$500
Total Annual:$4,250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$80,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$4,337
Cost per Remission
$4,337
Total Thyroidectomy Outcomes
for Hyperthyroidism
Efficacy Outcomes
Overall Effectiveness
+98%
Response Rate
+99%
Remission Rate
+99%
Common Side Effects
Hypothyroidism (requires lifelong levothyroxine)
+100%
Hypoparathyroidism (transient or permanent)
+5%
Recurrent laryngeal nerve injury (hoarseness)
+3%
Hematoma/bleeding
+1%
Infection
+1%
Active Clinical Trials
3 active trials recruiting for Total Thyroidectomy in Hyperthyroidism
Prevalence and Predictors of Incidental Thyroid Carcinoma in Patients With Graves' Disease Undergoing Thyroidectomy.
NCT07059507RECRUITING
280 participants
OBSERVATIONAL
Minya, Egypt
Started: Jul 15, 2025
A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy
NCT04776993RECRUITINGPHASE3
52 participants
INTERVENTIONAL
Pisa, Italy
Started: Mar 2, 2023
Clinical and Surgical Outcomes of Total Thyroidectomy in Basedow's Disease: the Effect of Lugol Solution
NCT05784792ENROLLING BY INVITATIONNA
50 participants
INTERVENTIONAL
Padua, Italy
Started: Feb 1, 2020
Completed Clinical Trials
4 completed trials for Total Thyroidectomy in Hyperthyroidism
Subtotal Versus Total Thyroidectomy for Graves' Disease
NCT01408368COMPLETEDNA
200 participants
INTERVENTIONAL
Krakow, Poland
Started: Jan 1, 2000
Calcium+Calcitriol Versus PTH for the Prevention of Hypocalcemia in Thyroidectomy. Randomized Clinical Trial
NCT05252884COMPLETEDNA
258 participants
INTERVENTIONAL
Medellín, Colombia +1 more
Started: Jun 30, 2022
Superficial Cervical Plexus Block With Dexmedetomidine Versus Without Adjuvant in Thyroid Surgery
NCT07274670COMPLETEDNA
58 participants
INTERVENTIONAL
Denpasar, Indonesia
Started: Jul 1, 2025
Thyrotropin Over-suppression and Heart
NCT02645786COMPLETED
31 participants
OBSERVATIONAL
Started: Sep 1, 2009