Levothyroxine
Treatment for Hypothyroidism
Typical Dosage: 25-200 mcg daily, titrated based on TSH
Effectiveness
90%
Safety Score
65%
Clinical Trials
132
Participants
1M
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
25-200 mcg daily, titrated based on TSH
Time to Effect
1-2 weeks for initial symptom improvement, 4-6 weeks for full thyroid hormone stabilization
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
500(Treat 500 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$300
Side Effect Mgmt:$10
Total Annual:$340
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$8,000/QALY
QALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$358
Cost per Remission
$358
Active Clinical Trials
4 active trials recruiting for Levothyroxine in Hypothyroidism
Novel Approaches to the Treatment of Hypothyroidism
NCT06731764RECRUITINGPHASE2, PHASE3
90 participants
INTERVENTIONAL
Farmington, United States
Started: Dec 10, 2024
Dosing of LT4 in Older Individuals
NCT06073665RECRUITINGPHASE4
228 participants
INTERVENTIONAL
Philadelphia, United States
Started: Jan 31, 2024
SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery Trial
NCT07421869RECRUITINGNA
107 participants
INTERVENTIONAL
Seongnam-si, South Korea
Started: Jun 12, 2024
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
NCT07380854RECRUITINGNA
338 participants
INTERVENTIONAL
Seongnam-si, South Korea
Started: Feb 27, 2022
Completed Clinical Trials
10 completed trials for Levothyroxine in Hypothyroidism
Levothyroxine Dosing in Neonatal Congenital Hypothyroidism
NCT07754370COMPLETEDPHASE4
101 participants
INTERVENTIONAL
Shibīn al Kawm, Egypt
Started: Nov 2, 2025
Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers
NCT01536678COMPLETEDPHASE4
26 participants
INTERVENTIONAL
Hyderabad, India
Started: Jan 1, 2012
Study of Optimal Replacement of Thyroxine in the Elderly
NCT01647750COMPLETEDPHASE4
48 participants
INTERVENTIONAL
Gateshead, United Kingdom +1 more
Started: Aug 1, 2012
Hypothyroidism, Metabolism and Food Intake
NCT02993562COMPLETED
18 participants
OBSERVATIONAL
Copenhagen, Denmark
Started: Aug 1, 2015
Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism
NCT02467244COMPLETED
120 participants
OBSERVATIONAL
Bhubaneswar, India
Started: Feb 1, 2017
Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism
NCT05371262COMPLETEDPHASE4
72 participants
INTERVENTIONAL
Started: May 1, 2011
Combined Therapy With L-Thyroxine and L-Triiodothyronine Compared to L-Thyroxine Alone
NCT00715572COMPLETEDNA
36 participants
INTERVENTIONAL
Started: Mar 1, 2002
Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism
NCT05823012COMPLETEDPHASE2
46 participants
INTERVENTIONAL
Chula Vista, United States +5 more
Started: May 15, 2023
Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition
NCT02891668COMPLETED
42 participants
OBSERVATIONAL
Herlev, Denmark
Started: May 1, 2015
Thyroid Hormone Dose Adjustment in Pregnancy
NCT00230802COMPLETEDNA
48 participants
INTERVENTIONAL
Boston, United States
Started: Jul 1, 2005
Showing 20 of 142 total trials