Valproate
Treatment for Idiopathic Epilepsy
Typical Dosage: 1000-2500 mg daily
Effectiveness
85%
Safety Score
50%
Clinical Trials
2
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
1000-2500 mg daily
Time to Effect
Days to weeks
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$800
Monitoring:$600
Side Effect Mgmt:$500
Total Annual:$1,900
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$12,667/QALY
QALYs Gained
7.5
Outcome-Based Costs
Cost per Responder
$3,455
Cost per Remission
$4,222
Valproate Outcomes
for Idiopathic Epilepsy
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+55%
Remission Rate
+45%
Common Side Effects
Nausea/Vomiting
+15%
Weight gain
+15%
Hair loss
+8%
Tremor
+7%
Sedation
+7%
Hepatotoxicity
+3%
Teratogenicity (major congenital malformations)
+7%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
2 completed trials for Valproate in Idiopathic Epilepsy
Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures
NCT03940326COMPLETEDPHASE4
103 participants
INTERVENTIONAL
Sari, Iran
Started: Apr 1, 2018
Levetiracetam Versus Valproate in Idiopathic Generalized Epilepsy
NCT06393309COMPLETED
169 participants
OBSERVATIONAL
Sari, Iran
Started: Sep 3, 2022