DFDA

Amitriptyline

Treatment for Interstitial Cystitis

Typical Dosage: 10-100mg daily

Effectiveness
60%
Safety Score
58%
Clinical Trials
3
Participants
4K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
58
DangerousModerateSafe
Treatment Details
Dosage Range
10-100mg daily
Time to Effect
4-8 weeks
Treatment Duration
Lifetime
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$500
Side Effect Mgmt:$100
Total Annual:$800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$52,865/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$1,777.78
Cost per Remission
$16,000
Amitriptyline Outcomes

for Interstitial Cystitis

Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+45%
Remission Rate
+5%
Common Side Effects
Dry mouth
+40%
Drowsiness
+30%
Constipation
+15%
Weight gain
+15%
Dizziness
+12%

Sources:

nih.gov
asclepiusopen.com
ics.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
2 active trials recruiting for Amitriptyline in Interstitial Cystitis

A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain

NCT05658874ACTIVE NOT RECRUITINGPHASE3
View Study
26 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Dec 1, 2022

EA for BPS: an RCT and Study for Central Mechanism

NCT05279963RECRUITINGNA
View Study
84 participants
INTERVENTIONAL
Hangzhou, China
Started: Mar 16, 2022
Completed Clinical Trials
1 completed trial for Amitriptyline in Interstitial Cystitis

Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)

NCT00124306COMPLETEDPHASE3
View Study
271 participants
INTERVENTIONAL
Stanford, United States +9 more
Started: Feb 1, 2005