Intensive Blood Pressure Lowering
Treatment for Intracerebral Hemorrhage
Typical Dosage: Target SBP < 140 mmHg within 1 hour
Effectiveness
80%
Safety Score
70%
Clinical Trials
8
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Target SBP < 140 mmHg within 1 hour
Time to Effect
Immediate (minutes to hours)
Treatment Duration
Acute phase (hours to days)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
28(Treat 28 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$3,000
Monitoring:$500
Side Effect Mgmt:$200
Total Annual:$3,700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$35,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$37,000
Intensive Blood Pressure Lowering Outcomes
for Intracerebral Hemorrhage
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+10%
Common Side Effects
Hypotension
+15%
Bradycardia
+2%
Sources:
Active Clinical Trials
4 active trials recruiting for Intensive Blood Pressure Lowering in Intracerebral Hemorrhage
Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage
NCT06760078NOT YET RECRUITINGPHASE4
532 participants
INTERVENTIONAL
Beijing, China +1 more
Started: Dec 31, 2024
International Care Bundle Evaluation in Cerebral Hemorrhage Research
NCT06429332RECRUITINGPHASE4
3.5K participants
INTERVENTIONAL
Sydney, Australia +13 more
Started: Jan 7, 2025
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage (EMINENT-ICH)
NCT05681988RECRUITINGNA
200 participants
INTERVENTIONAL
Basel, Switzerland +9 more
Started: Jan 1, 2024
ACT-GLOBAL Adaptive Platform Trial for Stroke
NCT06352632RECRUITINGPHASE3
20K participants
INTERVENTIONAL
Sydney, Australia +1 more
Started: Sep 26, 2024
Completed Clinical Trials
3 completed trials for Intensive Blood Pressure Lowering in Intracerebral Hemorrhage
The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial
NCT00716079COMPLETEDNA
2.84K participants
INTERVENTIONAL
Rochester, United States +61 more
Started: Sep 1, 2008
Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage
NCT00226096COMPLETEDNA
404 participants
INTERVENTIONAL
Concord, Australia +19 more
Started: Nov 1, 2005
The Third, Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial
NCT03209258COMPLETEDNA
7.07K participants
INTERVENTIONAL
Chengdu, China
Started: Dec 12, 2017