Low FODMAP Diet
Treatment for Irritable Bowel Syndrome
Typical Dosage: Adherence to dietary guidelines, often with dietitian guidance
Effectiveness
75%
Safety Score
90%
Clinical Trials
78
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe
Treatment Details
Dosage Range
Adherence to dietary guidelines, often with dietitian guidance
Time to Effect
1-4 weeks
Treatment Duration
Initial elimination (2-6 weeks), reintroduction (6-8 weeks), personalized long-term
Evidence Quality
MODERATENumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$800
Side Effect Mgmt:$0
Total Annual:$800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$10,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$1,667
Cost per Remission
$2,857
Comparison vs Standard IBS care (e.g., lifestyle advice, antispasmodics)
Cost Difference
+$500/year
More expensive
QALY Difference
+0.15 QALYs
Better outcomes
Dominance
No dominance
Low FODMAP Diet Outcomes
for Irritable Bowel Syndrome
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+35%
Common Side Effects
Dietary restriction challenges
+40%
Potential impact on gut microbiome
+20%
Nutritional inadequacy (if poorly managed)
+10%
Active Clinical Trials
6 active trials recruiting for Low FODMAP Diet in Irritable Bowel Syndrome
The Stool Microbiome of Treated and Untreated IBS (Irritable Bowel Syndrome) Patients
NCT05972317RECRUITINGNA
200 participants
INTERVENTIONAL
Rehovot, Israel
Started: Apr 10, 2024
Effect of a Low FODMAP Diet in IBS and Functional Constipation with Bloating: a Randomized Double-Blind Trial
NCT06871748NOT YET RECRUITINGNA
34 participants
INTERVENTIONAL
Started: Mar 15, 2025
Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS.
NCT05120752RECRUITINGPHASE3
60 participants
INTERVENTIONAL
Jette, Belgium
Started: Nov 2, 2021
Low FODMAP Plus PEG 3350 for the Treatment of Patients with Irritable Bowel Syndrome-Constipation
NCT03687814RECRUITINGNA
78 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Nov 8, 2018
Efficacy of the DOMINO Diet App in IBS
NCT05808036RECRUITINGNA
100 participants
INTERVENTIONAL
Leuven, Belgium
Started: Apr 1, 2023
Mechanism of FODMAP Restriction on FGID Patients
NCT07000227RECRUITINGNA
60 participants
INTERVENTIONAL
Kuala Lumpur, Malaysia
Started: Jul 20, 2025
Completed Clinical Trials
7 completed trials for Low FODMAP Diet in Irritable Bowel Syndrome
Effects of Low FODMAP Diet on Leaky Gut
NCT04526808COMPLETEDNA
14 participants
INTERVENTIONAL
Boston, United States +1 more
Started: May 20, 2019
Online Low-FODMAP Diet in Irritable Bowel Syndrome
NCT07172581COMPLETEDNA
40 participants
INTERVENTIONAL
Montreal, Canada
Started: May 23, 2020
Carbohydrate Reduction and Impact on Gastrointestinal System
NCT03729622COMPLETEDNA
65 participants
INTERVENTIONAL
Nottingham, United Kingdom
Started: Jan 1, 2016
The Effect of the Low FODMAP Diet and Dietary Oligofructose on Gastrointestinal Form, Function and Microbiota
NCT02259465COMPLETEDNA
45 participants
INTERVENTIONAL
Nottingham, United Kingdom
Started: Sep 1, 2014
Effects of Low FODMAP Diet on Colonic Epithelial Physiology in Diarrhea-predominant Irritable Bowel Syndrome
NCT04542018COMPLETEDNA
48 participants
INTERVENTIONAL
Boston, United States +1 more
Started: Aug 3, 2020
The Effects of FODMAPs in Patients With Irritable Bowel Syndrome
NCT05182593COMPLETEDNA
30 participants
INTERVENTIONAL
Gothenburg, Sweden
Started: Feb 1, 2019
Diet Reintroduction Study in Irritable Bowel Syndrome
NCT03052439COMPLETEDNA
20 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Jul 5, 2017
Showing 20 of 79 total trials