Isosorbide Mononitrate
Treatment for Ischemic Heart Disease
Typical Dosage: 20-120mg daily
Effectiveness
60%
Safety Score
70%
Clinical Trials
21
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
20-120mg daily
Time to Effect
30-60 minutes
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$50
Side Effect Mgmt:$25
Total Annual:$105
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$124
Isosorbide Mononitrate Outcomes
for Ischemic Heart Disease
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+85%
Common Side Effects
Headache
+25%
Hypotension
+10%
Dizziness
+5%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
11 completed trials for Isosorbide Mononitrate in Ischemic Heart Disease
Vericiguat Drug-drug Interaction Study With Isosorbite Mononitrate in Stable Coronary Artery Disease Patients
NCT03255512COMPLETEDPHASE1
41 participants
INTERVENTIONAL
Bad Krozingen, Germany +5 more
Started: Aug 17, 2017
Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina
NCT00143195COMPLETEDPHASE4
200 participants
INTERVENTIONAL
Athens, Greece +11 more
Started: Apr 1, 2001
Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina
NCT01769079COMPLETEDPHASE4
95 participants
INTERVENTIONAL
Porto Alegre, Brazil
Started: Sep 1, 2009
Intensive Arterial Pressure Control in Acute Coronary Syndrome
NCT02135315COMPLETEDNA
1.5K participants
INTERVENTIONAL
Monastir, Tunisia
Started: Mar 1, 2014
Asymptomatic Cardiac Ischemia Pilot (ACIP) Study
NCT00000478COMPLETEDPHASE3
INTERVENTIONAL
Started: Nov 1, 1990
A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis
NCT01513070COMPLETEDPHASE4
120 participants
INTERVENTIONAL
Beijing, China
Started: Apr 1, 2012
Microvascular Disease Exercise Trial
NCT02045459COMPLETEDNA
79 participants
INTERVENTIONAL
Charlottesville, United States +1 more
Started: May 1, 2014
Transradial Evaluation Study of Diameter Increase After Vasodilatory Drugs Administration.
NCT04317846COMPLETEDNA
165 participants
INTERVENTIONAL
Lausanne, Switzerland +1 more
Started: Mar 22, 2021
Prevalence of Extracardiac Coronary Collateral Supply Via the Internal Mammary Arteries
NCT01676207COMPLETED
120 participants
OBSERVATIONAL
Bern, Switzerland
Started: Jul 1, 2012
BIOTRONIK Orsiro Pre-Marketing Registration
NCT02870985COMPLETEDNA
440 participants
INTERVENTIONAL
Beijing, China
Started: Jul 14, 2015
Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease
NCT03011775COMPLETEDPHASE4
43 participants
INTERVENTIONAL
Poltava, Ukraine
Started: Nov 1, 2012
Showing 20 of 21 total trials