Metoprolol
Treatment for Ischemic Heart Disease
Typical Dosage: 25-200mg daily
Effectiveness
78%
Safety Score
70%
Clinical Trials
47
Participants
120K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
25-200mg daily
Time to Effect
immediate
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
40(Treat 40 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
300(Treat 300 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$25
Monitoring:$100
Side Effect Mgmt:$20
Total Annual:$145
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$207
Comparison vs No treatment
Cost Difference
+$145/year
More expensive
QALY Difference
+1.00 QALYs
Better outcomes
Dominance
No dominance
Metoprolol Outcomes
for Ischemic Heart Disease
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+70%
Common Side Effects
Bradycardia
+10%
Fatigue
+15%
Hypotension
+8%
Active Clinical Trials
3 active trials recruiting for Metoprolol in Ischemic Heart Disease
Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease
NCT07268170ENROLLING BY INVITATIONPHASE2, PHASE3
350 participants
INTERVENTIONAL
Herning, Denmark
Started: Dec 15, 2025
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
NCT06864234RECRUITINGPHASE4
46 participants
INTERVENTIONAL
Aalst, Belgium
Started: Jul 3, 2025
Coronary Atherosclerosis T1-Weighted Characterization (CATCH)
NCT03504956RECRUITINGNA
150 participants
INTERVENTIONAL
Los Angeles, United States
Started: Jul 30, 2018
Completed Clinical Trials
8 completed trials for Metoprolol in Ischemic Heart Disease
Metoprolol to Reduce Perioperative Myocardial Injury
NCT03138603COMPLETEDPHASE3
72 participants
INTERVENTIONAL
Chicago, United States +1 more
Started: Dec 1, 2016
A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
NCT00756236COMPLETEDNA
60 participants
INTERVENTIONAL
Oklahoma City, United States
Started: Oct 1, 2008
Evaluation of Succinate Metoprolol on Heart Rate in the Stable Angina Patients
NCT01213173COMPLETEDPHASE4
251 participants
INTERVENTIONAL
Beijing, China +9 more
Started: Oct 1, 2010
Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
NCT00198614COMPLETEDNA
650 participants
INTERVENTIONAL
Suita, Japan
Started: Jan 1, 2005
Metoprolol and Trimetazidine for Coronary Heart Disease With Angina
NCT07074834COMPLETEDNA
102 participants
INTERVENTIONAL
Shiyan, China
Started: Feb 1, 2021
Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain
NCT00718406COMPLETEDPHASE4
INTERVENTIONAL
Gothenburg, Sweden
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome
NCT02809820COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Naples, Italy
Started: May 1, 2016
Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
NCT03579914COMPLETEDNA
1.21K participants
INTERVENTIONAL
Beijing, China +15 more
Started: Nov 28, 2017
Showing 20 of 48 total trials