DFDA

Hydrochlorothiazide (HCTZ)

Treatment for Kidney Stones

Typical Dosage: 12.5-50mg daily

Effectiveness
75%
Safety Score
65%
Clinical Trials
7
Participants
7K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
12.5-50mg daily
Time to Effect
Weeks to months
Treatment Duration
Long-term/Lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
20(Treat 20 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$200
Side Effect Mgmt:$100
Total Annual:$350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$25,000/QALY
QALYs Gained
0.9
Outcome-Based Costs
Cost per Responder
$467
Cost per Remission
$583
Hydrochlorothiazide (HCTZ) Outcomes

for Kidney Stones

Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+60%
Common Side Effects
Hypokalemia (low potassium)
+15%
Hypotension/Dizziness
+7%
Hyperglycemia, Hyperuricemia
+7%

Sources:

nih.gov
nih.gov
kidneynews.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Hydrochlorothiazide (HCTZ) in Kidney Stones

Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention

NCT06111885RECRUITINGPHASE2
View Study
99 participants
INTERVENTIONAL
Bern, Switzerland
Started: Oct 1, 2024
Completed Clinical Trials
3 completed trials for Hydrochlorothiazide (HCTZ) in Kidney Stones

Use of Nanotechnology Structured Water for the Prevention of Recurrent Stone Formation

NCT06681116COMPLETEDNA
View Study
325 participants
INTERVENTIONAL
Sulaymaniyah, Iraq
Started: Feb 16, 2015

Hydrochlorothiazide for Kidney Stone Recurrence Prevention

NCT03057431COMPLETEDPHASE3
View Study
416 participants
INTERVENTIONAL
Aarau, Switzerland +11 more
Started: Mar 9, 2017

Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium

NCT02711670COMPLETEDNA
View Study
10 participants
INTERVENTIONAL
New York, United States
Started: Feb 1, 2014