Total Laryngectomy (Surgery)
Treatment for Larynx Cancer
Typical Dosage: Surgical removal of the larynx
Effectiveness
90%
Safety Score
40%
Clinical Trials
14
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
Surgical removal of the larynx
Time to Effect
Immediate
Treatment Duration
Single procedure, followed by lifelong rehabilitation
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$7,000
Side Effect Mgmt:$10,000
Total Annual:$75,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$70,000/QALY
QALYs Gained
3
Outcome-Based Costs
Cost per Responder
$83,333
Cost per Remission
$93,750
Total Laryngectomy (Surgery) Outcomes
for Larynx Cancer
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+80%
Common Side Effects
Permanent tracheostomy
+100%
Aphonia (loss of voice)
+100%
Dysphagia (swallowing difficulties)
+50%
Stoma care complications
+30%
Fistula formation
+10%
Infection
+15%
Sources:
Active Clinical Trials
4 active trials recruiting for Total Laryngectomy (Surgery) in Larynx Cancer
Study Title: Oncological and Functional Results After Total Laryngectomy and Pharyngolaryngectomy
NCT07287865ACTIVE NOT RECRUITING
400 participants
OBSERVATIONAL
Pavia, Italy
Started: Mar 14, 2025
Intralesional Chemotherapy (IC): Cisplatin + Epinephrine
NCT07392580RECRUITINGPHASE2
20 participants
INTERVENTIONAL
Miami, United States
Started: Dec 1, 2026
The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)
NCT06287034RECRUITING
102 participants
OBSERVATIONAL
Rome, Italy
Started: Mar 21, 2023
Quality of Life and Functional Outcomes in Laryngeal Cancer Patients
NCT07320820NOT YET RECRUITING
120 participants
OBSERVATIONAL
Started: Apr 2, 2026
Completed Clinical Trials
7 completed trials for Total Laryngectomy (Surgery) in Larynx Cancer
Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx
NCT02739958COMPLETEDNA
40 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Mar 1, 2016
The Efficacy of Superficial Cervical Block Application in Postoperative Analgesia Management in Patients Undergoing Total Laryngectomy and Bilateral Neck Dissection
NCT06852651COMPLETEDNA
50 participants
INTERVENTIONAL
Istanbul, Turkey (Türkiye)
Started: Mar 10, 2025
Clinical Feasibility of New Tracheoesophageal Puncture Set
NCT01045057COMPLETEDNA
27 participants
INTERVENTIONAL
Leuven, Belgium +4 more
Started: Dec 1, 2009
Phonatory Movement of the Pharyngoesophageal Mucosa in Laryngectomy Patients
NCT05561920COMPLETED
55 participants
OBSERVATIONAL
Osijek, Croatia
Started: Aug 1, 2022
TPF Plus Radiotherapy and Cetuximab to Avoid Total Laryngectomy in Patients With Larynx Cancer
NCT00765011COMPLETEDPHASE2
94 participants
INTERVENTIONAL
Badalona, Spain +16 more
Started: Oct 1, 2008
Validation and Cross-cultural Adaptation of Croatian SECEL Questionnaire
NCT05346237COMPLETED
50 participants
OBSERVATIONAL
Osijek, Croatia
Started: Oct 7, 2021
Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal
NCT03461328COMPLETEDPHASE4
40 participants
INTERVENTIONAL
Cairo, Egypt
Started: Apr 20, 2018