DFDA

Memantine

Treatment for Lewy Body Dementia

Typical Dosage: 5-20 mg daily, titrated

Effectiveness
55%
Safety Score
70%
Clinical Trials
4
Participants
1.6K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
5-20 mg daily, titrated
Time to Effect
2-4 weeks
Treatment Duration
lifetime
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$750
Side Effect Mgmt:$75
Total Annual:$900
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$12,857/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$3,600
Prescription Access Economics
Annual Societal Loss per Patient
$655
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$240/year
Prior auth, claims
Rx Price
$75/year
Potential OTC Price
$30/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Memantine Outcomes

for Lewy Body Dementia

Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+25%
Common Side Effects
Dizziness
+8%
Headache
+7%
Confusion
+4%
Constipation
+4%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
4 completed trials for Memantine in Lewy Body Dementia

Memantine Versus Placebo in Parkinson's Disease Dementia or Dementia With Lewy Bodies

NCT00855686COMPLETEDPHASE4
View Study
199 participants
INTERVENTIONAL
Munich, Germany
Started: Jan 1, 2007

Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)

NCT00630500COMPLETEDPHASE2
View Study
75 participants
INTERVENTIONAL
Stavanger, Norway +3 more
Started: Feb 1, 2006

Monitoring Anti-Dementia Drugs by Serum Levels

NCT04117178COMPLETEDPHASE4
View Study
132 participants
INTERVENTIONAL
Roskilde, Denmark
Started: Feb 4, 2020

COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE

NCT02860338COMPLETED
View Study
900 participants
OBSERVATIONAL
Started: Jan 1, 2009