Cisplatin (with Radiation Therapy)
Treatment for Lip And Oral Cavity Cancer
Typical Dosage: 40 mg/m2 weekly or 100 mg/m2 every 3 weeks
Effectiveness
80%
Safety Score
25%
Clinical Trials
61
Participants
150K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
40 mg/m2 weekly or 100 mg/m2 every 3 weeks
Time to Effect
Within weeks of starting, sustained benefit over months
Treatment Duration
Weekly for 6-7 weeks during radiation
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,500
Monitoring:$10,000
Side Effect Mgmt:$12,000
Total Annual:$23,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$95,000/QALY
QALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$31,333
Cost per Remission
$36,154
Comparison vs Radiation Therapy alone
Cost Difference
+$23,500/year
More expensive
QALY Difference
+0.80 QALYs
Better outcomes
Dominance
No dominance
Cisplatin (with Radiation Therapy) Outcomes
for Lip And Oral Cavity Cancer
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+75%
Remission Rate
+65%
Common Side Effects
Nausea/Vomiting
+80%
Nephrotoxicity
+40%
Ototoxicity
+30%
Myelosuppression
+25%
Fatigue
+70%
Active Clinical Trials
3 active trials recruiting for Cisplatin (with Radiation Therapy) in Lip And Oral Cavity Cancer
Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial
NCT07121595RECRUITINGPHASE2
50 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Jul 17, 2025
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
NCT02734537RECRUITINGPHASE2
189 participants
INTERVENTIONAL
Birmingham, United States +639 more
Started: Nov 23, 2016
Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma
NCT03174275ACTIVE NOT RECRUITINGPHASE2
39 participants
INTERVENTIONAL
Chapel Hill, United States +1 more
Started: Dec 19, 2017
Completed Clinical Trials
13 completed trials for Cisplatin (with Radiation Therapy) in Lip And Oral Cavity Cancer
Chemotherapy, Radiation Therapy, and Cetuximab in Treating Patients With the Head and Neck Cancer
NCT00875849COMPLETEDPHASE2
53 participants
INTERVENTIONAL
Nice, France
Started: Mar 1, 2008
Cytochlor and Tetrahydrouridine as Radiosensitizers and Cisplatin Combined With Radiation Therapy in Treating Patients With Advanced Squamous Cell Carcinoma of the Oral Cavity (Mouth) or Oropharynx (Throat)
NCT00077051COMPLETEDPHASE1
1 participants
INTERVENTIONAL
Miami, United States
Started: Apr 1, 2004
Radiation Therapy Cisplatin With or Without Fluorouracil Patients With Stage III or Stage IV Head and Neck Cancer
NCT00608205COMPLETEDPHASE3
69 participants
INTERVENTIONAL
Cleveland, United States +1 more
Started: Jan 1, 2008
Erlotinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Mouth or Throat Cancer
NCT00049166COMPLETEDPHASE1
48 participants
INTERVENTIONAL
Baltimore, United States
Started: Oct 1, 2002
Radiation Therapy and Cisplatin in Treating Patients With Advanced Head and Neck Cancer
NCT00005088COMPLETEDPHASE2
INTERVENTIONAL
Birmingham, United States +257 more
Started: Apr 1, 2000
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer
NCT00006051COMPLETEDPHASE2
INTERVENTIONAL
Clermont-Ferrand, France +5 more
Started: Feb 1, 1999
Cisplatin and Radiation Therapy in Treating Patients With Stage IV Cancer of the Head and Neck
NCT00002932COMPLETEDPHASE2
60 participants
INTERVENTIONAL
La Jolla, United States +12 more
Started: May 1, 1997
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer
NCT00003888COMPLETEDPHASE3
359 participants
INTERVENTIONAL
Graz, Austria +43 more
Started: Apr 1, 1999
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
NCT00021333COMPLETEDPHASE2
29 participants
INTERVENTIONAL
Flemington, United States +17 more
Started: Sep 1, 1999
Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Advanced Stage III or Stage IV Head and Neck Cancer
NCT00005814COMPLETEDPHASE2
INTERVENTIONAL
New York, United States
Started: Dec 1, 1999
Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck
NCT00096174COMPLETEDPHASE2
69 participants
INTERVENTIONAL
Started: Apr 8, 2005
Radiation + Cisplatin or Panitumumab in Locally Advanced Stage III or Stage IV Head and Neck Cancer
NCT00820248COMPLETEDPHASE3
320 participants
INTERVENTIONAL
Edmonton, Canada +18 more
Started: Dec 30, 2008
Chemotherapy and Radiation Therapy Following Surgery in Treating Patients With Head and Neck Cancer
NCT00011999COMPLETEDPHASE2
70 participants
INTERVENTIONAL
Birmingham, United States +233 more
Started: Mar 1, 2001
Showing 20 of 61 total trials