Amoxicillin/Clavulanate
Treatment for Lower Respiratory Infections
Typical Dosage: 875 mg/125 mg twice daily
Effectiveness
88%
Safety Score
70%
Clinical Trials
1
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
875 mg/125 mg twice daily
Time to Effect
1-2 days
Treatment Duration
7-10 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$45
Monitoring:$250
Side Effect Mgmt:$10
Total Annual:$305
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.09
Outcome-Based Costs
Cost per Responder
$338.89
Cost per Remission
$358.82
Comparison vs Amoxicillin
Cost Difference
+$30/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Physician Visit Cost
$150/year
Time Cost
$30/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$45/year
Potential OTC Price
$27.5/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATEMissed Diagnosis Risk
LOWAmoxicillin/Clavulanate Outcomes
for Lower Respiratory Infections
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Diarrhea
+12%
Nausea/vomiting
+6%
Rash
+2%
Hepatotoxicity
+0.05%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Amoxicillin/Clavulanate in Lower Respiratory Infections
Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections
NCT01660204COMPLETEDNA
2.28K participants
INTERVENTIONAL
Alkmaar, Netherlands +6 more
Started: Feb 1, 2011