Chloroquine Phosphate
Treatment for Malaria
Typical Dosage: Adults: 1000mg salt initially, then 500mg at 6-8 hours, then 500mg daily for 2 more days
Effectiveness
97%
Safety Score
70%
Clinical Trials
131
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Adults: 1000mg salt initially, then 500mg at 6-8 hours, then 500mg daily for 2 more days
Time to Effect
2-3 days
Treatment Duration
3 days
Evidence Quality
HIGHConfidence Score
92%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$2
Monitoring:$20
Side Effect Mgmt:$5
Total Annual:$27
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$27.8
Cost per Remission
$27.8
Chloroquine Phosphate Outcomes
for Malaria
Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+97%
Common Side Effects
Pruritus
+50%
Nausea/Vomiting
+20%
Abdominal pain
+10%
Headache
+10%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
16 completed trials for Chloroquine Phosphate in Malaria
Evaluating the Role of Chloroquine for Malaria Elimination
NCT02698748COMPLETEDPHASE2, PHASE3
75 participants
INTERVENTIONAL
Manhiça, Mozambique
Started: Jan 1, 2015
Effectiveness of Malaria Treatment in Mexico
NCT02394197COMPLETEDPHASE4
153 participants
INTERVENTIONAL
Started: Feb 1, 2008
Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax
NCT06044805COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Arba Minch, Ethiopia
Started: Dec 19, 2022
Dose Escalation PfSPZ-CVac
NCT03083847COMPLETEDPHASE1
55 participants
INTERVENTIONAL
Bethesda, United States
Started: Jun 5, 2017
Chloroquine Population Pharmacokinetics in Pre and Post-partum Women
NCT01546961COMPLETEDNA
49 participants
INTERVENTIONAL
Tak, Thailand
Started: Jun 1, 2011
Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...
NCT03952650COMPLETEDPHASE1, PHASE2
252 participants
INTERVENTIONAL
Bamako, Mali
Started: May 23, 2019
G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)
NCT01205178COMPLETEDPHASE1
192 participants
INTERVENTIONAL
Bangkok, Thailand +1 more
Started: Jul 2, 2009
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
NCT03529396COMPLETEDPHASE2
106 participants
INTERVENTIONAL
Manaus, Brazil +1 more
Started: Jul 20, 2018
Pharmacokinetic Study of Multi-dose Chloroquine
NCT01814423COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Bissau, Guinea-Bissau
Started: Apr 1, 2013
Estimating the Risk of Plasmodium Vivax Relapses in Afghanistan
NCT01178021COMPLETEDPHASE4
593 participants
INTERVENTIONAL
Maymana, Afghanistan +2 more
Started: Aug 1, 2009
TES of Chloroquine for Pv in the Philippines in 2016
NCT05958797COMPLETED
74 participants
OBSERVATIONAL
Started: Jan 4, 2016
Chloroquine and Post Malaria Anaemia Study
NCT00473837COMPLETEDNA
96 participants
INTERVENTIONAL
Started: Jul 1, 2007
Chloroquine for Malaria in Pregnancy
NCT01443130COMPLETEDPHASE3
900 participants
INTERVENTIONAL
Blantryre, Malawi
Started: Feb 1, 2012
Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan
NCT01019408COMPLETEDPHASE4
163 participants
INTERVENTIONAL
Adezai, Pakistan +2 more
Started: Nov 1, 1993
Study on the Treatment of Vivax Malaria
NCT01074905COMPLETEDPHASE3
655 participants
INTERVENTIONAL
Mae Sot, Thailand
Started: May 1, 2010
Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India
NCT00074841COMPLETEDPHASE2, PHASE3
230 participants
INTERVENTIONAL
Dispur Guwahati, India +6 more
Started: Sep 1, 2003
Showing 20 of 131 total trials