Primaquine
Treatment for Malaria
Typical Dosage: Adults: 0.25mg/kg daily for 14 days (P. vivax/ovale radical cure)
Effectiveness
92%
Safety Score
60%
Clinical Trials
120
Participants
40K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Adults: 0.25mg/kg daily for 14 days (P. vivax/ovale radical cure)
Time to Effect
Weeks to months for relapse prevention; days for gametocyte clearance
Treatment Duration
14 days (daily) for radical cure; single dose for gametocyte clearance
Evidence Quality
HIGHConfidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$5
Monitoring:$75
Side Effect Mgmt:$20
Total Annual:$100
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$108.7
Cost per Remission
$108.7
Comparison vs No radical cure (for P. vivax/ovale)
Cost Difference
+$100/year
More expensive
QALY Difference
+0.10 QALYs
Better outcomes
Dominance
No dominance
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
17 completed trials for Primaquine in Malaria
Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Children
NCT05044637COMPLETEDPHASE2
100 participants
INTERVENTIONAL
Cruzeiro do Sul, Brazil +1 more
Started: Aug 26, 2021
Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1
NCT02898779COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Oxford, United States
Started: May 1, 2017
Short Course Radical Cure of P. Vivax Malaria in Nepal
NCT04079621COMPLETEDPHASE4
27 participants
INTERVENTIONAL
Malakheti, Nepal +1 more
Started: Oct 27, 2021
Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda
NCT01365598COMPLETEDPHASE3
468 participants
INTERVENTIONAL
Jinja, Uganda
Started: Dec 1, 2011
Determining a Tolerable Dose of Primaquine in G6PD-deficient Persons Without Malaria in Mali
NCT02535767COMPLETEDPHASE1, PHASE2
28 participants
INTERVENTIONAL
Bamako, Mali
Started: Aug 1, 2015
Single Low-dose Primaquine Efficacy and Safety.
NCT03352843COMPLETEDPHASE4
157 participants
INTERVENTIONAL
Arusha, Tanzania
Started: Jun 11, 2019
Eight Week Primaquine Regimen for the Treatment of Vivax Malaria
NCT00158587COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Started: Apr 1, 2004
Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas
NCT03916003COMPLETEDPHASE4
500 participants
INTERVENTIONAL
Upazila, Bangladesh +2 more
Started: Aug 18, 2019
Effectiveness of Mass Drug Administration for Reducing Seasonal Malaria Transmission in Zanzibar
NCT02721186COMPLETEDNA
22.5K participants
INTERVENTIONAL
Mwanakwerekwe, Tanzania
Started: Apr 30, 2016
Primaquine Pharmacokinetics in Lactating Women and Their Infants
NCT01780753COMPLETEDPHASE1
20 participants
INTERVENTIONAL
Mae Sot, Thailand
Started: Dec 1, 2012
IMPROV (Improving the Radical Cure of Vivax Malaria)
NCT01814683COMPLETEDNA
2.39K participants
INTERVENTIONAL
Jalalabad, Afghanistan +7 more
Started: Jul 1, 2014
Incidence of Vivax Along the Thai Burma Border
NCT01076868COMPLETEDNA
403 participants
INTERVENTIONAL
Mae Sot, Thailand
Started: Feb 1, 2010
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
NCT03529396COMPLETEDPHASE2
106 participants
INTERVENTIONAL
Manaus, Brazil +1 more
Started: Jul 20, 2018
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil
NCT03610399COMPLETEDNA
257 participants
INTERVENTIONAL
Cruzeiro do Sul, Brazil
Started: Apr 9, 2018
Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil
NCT02043652COMPLETEDNA
119 participants
INTERVENTIONAL
Cruzeiro do Sul, Brazil
Started: Feb 1, 2014
Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax
NCT06044805COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Arba Minch, Ethiopia
Started: Dec 19, 2022
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
NCT04411836COMPLETEDPHASE3
960 participants
INTERVENTIONAL
Pursat, Cambodia +5 more
Started: Apr 25, 2021
Showing 20 of 121 total trials