DFDA

Quinine Sulfate + Doxycycline

Treatment for Malaria

Typical Dosage: Quinine: 600mg salt 3 times daily for 7 days. Doxycycline: 100mg daily for 7 days

Effectiveness
90%
Safety Score
60%
Clinical Trials
1
Participants
30K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Quinine: 600mg salt 3 times daily for 7 days. Doxycycline: 100mg daily for 7 days
Time to Effect
2-4 days
Treatment Duration
7 days (quinine) + 7 days (doxycycline)
Evidence Quality
HIGH
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$35
Monitoring:$100
Side Effect Mgmt:$30
Total Annual:$165
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$183.3
Cost per Remission
$183.3
Comparison vs Artemether-Lumefantrine (if ACT fails)
Cost Difference
+$95/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
Quinine Sulfate + Doxycycline Outcomes

for Malaria

Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Cinchonism (tinnitus, headache, nausea, visual disturbances)
+50%
Hypoglycemia
+10%
QTc prolongation
+30%
Photosensitivity (doxycycline)
+10%

Sources:

hiv.gov
who.int
cdc.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Quinine Sulfate + Doxycycline in Malaria

Artemisinin Resistance in Bangladesh

NCT00639873COMPLETEDNA
View Study
126 participants
INTERVENTIONAL
Bandarban Sadar, Bangladesh
Started: Jun 1, 2008