Intratympanic Gentamicin
Treatment for Menieres Disease
Typical Dosage: 20-40 mg/mL, 0.3-0.5 mL per injection
Effectiveness
83%
Safety Score
55%
Clinical Trials
2
Participants
4.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
20-40 mg/mL, 0.3-0.5 mL per injection
Time to Effect
Days to weeks
Treatment Duration
1-4 injections per series
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$600
Side Effect Mgmt:$300
Total Annual:$2,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
0.55
Outcome-Based Costs
Cost per Responder
$2,941
Cost per Remission
$3,571
Comparison vs Intratympanic Dexamethasone
Cost Difference
+$500/year
More expensive
QALY Difference
+0.10 QALYs
Better outcomes
Dominance
No dominance
Intratympanic Gentamicin Outcomes
for Menieres Disease
Efficacy Outcomes
Overall Effectiveness
+83%
Response Rate
+88%
Remission Rate
+70%
Common Side Effects
Permanent hearing loss
+20%
Transient vertigo
+15%
Ear discomfort
+8%
Tinnitus
+7%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov