Vancomycin
Treatment for Meningitis
Typical Dosage: 15-20 mg/kg IV every 8-12 hours with TDM
Effectiveness
88%
Safety Score
65%
Clinical Trials
4
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
15-20 mg/kg IV every 8-12 hours with TDM
Time to Effect
immediate
Treatment Duration
10-21 days
Evidence Quality
HIGHConfidence Score
92%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$700
Monitoring:$1,500
Side Effect Mgmt:$750
Total Annual:$2,950
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
Outcome-Based Costs
Cost per Responder
$3,352
Cost per Remission
$3,782
Vancomycin Outcomes
for Meningitis
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+88%
Remission Rate
+78%
Common Side Effects
Red Man Syndrome
+7%
Nephrotoxicity
+10%
Ototoxicity
+0.5%
Sources:
Active Clinical Trials
1 active trial recruiting for Vancomycin in Meningitis
Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
NCT04771884RECRUITING
300 participants
OBSERVATIONAL
Chongqing, China
Started: Oct 1, 2020
Completed Clinical Trials
3 completed trials for Vancomycin in Meningitis
Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections
NCT00427076COMPLETEDPHASE3
252 participants
INTERVENTIONAL
Haifa, Israel +1 more
Started: Jun 1, 2007
Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis
NCT00162578COMPLETED
14 participants
OBSERVATIONAL
Colombes, France +2 more
Started: Dec 1, 2002
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
NCT01431326COMPLETED
3.52K participants
OBSERVATIONAL
Anchorage, United States +51 more
Started: Nov 1, 2011