Propranolol
Treatment for Migraine
Typical Dosage: 80-240mg daily, titrated
Effectiveness
65%
Safety Score
62%
Clinical Trials
26
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
62
DangerousModerateSafe
Treatment Details
Dosage Range
80-240mg daily, titrated
Time to Effect
2-4 weeks
Treatment Duration
Long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$300
Side Effect Mgmt:$200
Total Annual:$600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,500
Cost per Remission
$7,500
Propranolol Outcomes
for Migraine
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+40%
Remission Rate
+8%
Common Side Effects
Fatigue
+15%
Dizziness
+10%
Bradycardia
+8%
Hypotension
+5%
Nausea
+5%
Active Clinical Trials
6 active trials recruiting for Propranolol in Migraine
Zonisamide Versus Propranolol in Migraine
NCT06361446RECRUITINGPHASE3
600 participants
INTERVENTIONAL
Kafr ash Shaykh, Egypt
Started: Mar 29, 2024
Valproate Versus Propranolol in Migraine
NCT06485726RECRUITINGPHASE4
600 participants
INTERVENTIONAL
Kafr ash Shaykh, Egypt
Started: Jan 23, 2023
Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care
NCT06499116NOT YET RECRUITINGPHASE4
460 participants
INTERVENTIONAL
Started: Oct 1, 2024
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
NCT06972056RECRUITINGPHASE4
1.33K participants
INTERVENTIONAL
Flagstaff, United States +8 more
Started: Jul 9, 2025
Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine
NCT07147972NOT YET RECRUITINGPHASE3
100 participants
INTERVENTIONAL
Started: Aug 20, 2025
Impact of Combined Oral Contraceptive Pills on Migraine
NCT06509503RECRUITINGPHASE4
400 participants
INTERVENTIONAL
Kafr ash Shaykh, Egypt
Started: Jul 15, 2024
Completed Clinical Trials
11 completed trials for Propranolol in Migraine
Lacosamide Versus Propranolol in Migraine
NCT05851781COMPLETEDPHASE3
600 participants
INTERVENTIONAL
Kafr ash Shaykh, Egypt
Started: Jun 1, 2022
A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine
NCT00236561COMPLETEDPHASE3
786 participants
INTERVENTIONAL
Started: Apr 1, 2001
Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine
NCT02350985COMPLETEDPHASE4
73 participants
INTERVENTIONAL
Istanbul, Turkey (Türkiye)
Started: Jan 1, 2014
Candesartan Versus Propranolol for Migraine Prevention
NCT00884663COMPLETEDPHASE2, PHASE3
72 participants
INTERVENTIONAL
Trondheim, Norway
Started: Apr 1, 2009
Comorbidity-Based Propranolol Use in Pediatric Migraine
NCT07103031COMPLETED
488 participants
OBSERVATIONAL
Kayseri, Turkey (Türkiye)
Started: Jan 1, 2021
Effectivity and Safety of GB20 Acupoint Pharmacopuncture With Lidocaine 2% on Migraine Patients
NCT07067853COMPLETEDNA
30 participants
INTERVENTIONAL
Jakarta Pusat, Indonesia
Started: Sep 1, 2025
Caffeine/Propranolol Intervention for Acute Migraine
NCT01080677COMPLETEDPHASE2
60 participants
INTERVENTIONAL
Stanford, United States
Started: Jan 1, 2007
NINDS CRC Chronic Migraine Treatment Trial
NCT00772031COMPLETEDPHASE3
191 participants
INTERVENTIONAL
Phoenix, United States +38 more
Started: Oct 1, 2008
Propranolol for Pediatric Migraine: A Prospective Clinical Study
NCT07180043COMPLETEDNA
178 participants
INTERVENTIONAL
Kayseri, Turkey (Türkiye)
Started: Jan 1, 2021
An Efficacy and Tolerability Study of Topiramate in Participants With Migraine
NCT01060111COMPLETEDPHASE4
250 participants
INTERVENTIONAL
Busan, South Korea +5 more
Started: Jul 1, 2006
Drug and Non-Drug Treatment Of Severe Migraine
NCT00910689COMPLETEDPHASE4
232 participants
INTERVENTIONAL
Athens, United States +1 more
Started: Jul 1, 2001
Showing 20 of 26 total trials