Folic Acid Supplementation (Prevention)
Treatment for Neural Tube Defects
Typical Dosage: 0.4mg-4mg daily
Effectiveness
70%
Safety Score
90%
Clinical Trials
1,000
Participants
1M
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe
Treatment Details
Dosage Range
0.4mg-4mg daily
Time to Effect
Ongoing during periconceptional period
Treatment Duration
Periconceptional period (at least 1 month before conception through first trimester), or for all women of childbearing age
Evidence Quality
HIGHNumber Needed to Treat (NNT)
150(Treat 150 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$1,000
Side Effect Mgmt:$0
Total Annual:$1,015
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
25
Outcome-Based Costs
Cost per Responder
$21.43
Comparison vs No folic acid supplementation
Cost Difference
$-100,000/year
Less expensive
QALY Difference
+25.00 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Folic Acid Supplementation (Prevention) Outcomes
for Neural Tube Defects
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Common Side Effects
Nausea
+1%
Bloating
+1%
Loss of appetite
+1%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov