Methadone
Treatment for Opioid Use Disorders
Typical Dosage: 60-120 mg daily, orally, in a supervised clinic
Effectiveness
88%
Safety Score
50%
Clinical Trials
124
Participants
200K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
60-120 mg daily, orally, in a supervised clinic
Time to Effect
Immediate (stabilization 1-2 weeks)
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
80(Treat 80 patients to see 1 additional serious adverse event)
Confidence Score
98%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$240
Monitoring:$6,500
Side Effect Mgmt:$100
Total Annual:$6,840
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$40,000/QALY
QALYs Gained
0.45
Outcome-Based Costs
Cost per Responder
$9,120
Cost per Remission
$13,680
Comparison vs No treatment
Cost Difference
+$6,840/year
More expensive
QALY Difference
+0.45 QALYs
Better outcomes
Dominance
No dominance
Methadone Outcomes
for Opioid Use Disorders
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Remission Rate
+50%
Common Side Effects
Constipation
+30%
Sweating
+30%
Drowsiness
+20%
Nausea/Vomiting
+10%
QT prolongation/cardiac effects (rare but serious)
+1%
Respiratory depression
+5%
Sources:
Active Clinical Trials
9 active trials recruiting for Methadone in Opioid Use Disorders
MethaLoad Dose-Finding Study
NCT06877858RECRUITINGPHASE1
24 participants
INTERVENTIONAL
Philadelphia, United States
Started: Sep 25, 2025
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
NCT06323824RECRUITINGPHASE4
600 participants
INTERVENTIONAL
Oakland, United States +5 more
Started: Jun 4, 2024
Assessing Concentrations of Methadone and Its Metabolites
NCT06835582ENROLLING BY INVITATION
20 participants
OBSERVATIONAL
Lemon Grove, United States
Started: Mar 17, 2025
Symptom-inhibited Fentanyl Induction
NCT05905367RECRUITINGPHASE4
50 participants
INTERVENTIONAL
Vancouver, Canada
Started: Jan 29, 2024
Treating Polysubstance Use Using a Novel Digital Technology
NCT05766631RECRUITINGPHASE3
240 participants
INTERVENTIONAL
Baltimore, United States +4 more
Started: Jul 26, 2023
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy
NCT05942313RECRUITING
100 participants
OBSERVATIONAL
Pittsburgh, United States
Started: Aug 28, 2023
Divided or Single Exposure (DOSE) Study
NCT05459402RECRUITINGPHASE2, PHASE3
150 participants
INTERVENTIONAL
Baltimore, United States
Started: Feb 21, 2023
Remotely Observed Methadone Evaluation II
NCT06338280RECRUITINGPHASE2
100 participants
INTERVENTIONAL
Chicago, United States
Started: Dec 24, 2024
Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering
NCT05924022ACTIVE NOT RECRUITINGPHASE1
36 participants
INTERVENTIONAL
Spokane, United States
Started: Dec 4, 2023
Completed Clinical Trials
9 completed trials for Methadone in Opioid Use Disorders
A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse
NCT03033732COMPLETEDPHASE4
272 participants
INTERVENTIONAL
Calgary, Canada +6 more
Started: Oct 2, 2017
Opioid Treatment Program (OTP)-Pharmacy Collaboration for Methadone Maintenance Treatment
NCT04308694COMPLETEDEARLY_PHASE1
20 participants
INTERVENTIONAL
Raleigh, United States +2 more
Started: Aug 6, 2020
Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder
NCT02502175COMPLETEDPHASE3
204 participants
INTERVENTIONAL
Moḩammadābād, Iran +3 more
Started: Jun 22, 2017
Remotely Observed Methadone Evaluation
NCT06200740COMPLETEDNA
24 participants
INTERVENTIONAL
Roseburg, United States
Started: Sep 25, 2022
A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail
NCT02334215COMPLETEDNA
225 participants
INTERVENTIONAL
Baltimore, United States
Started: Dec 15, 2014
Remote Methadone Ingestion Surveillance Trial (RMIST)
NCT05259501COMPLETEDNA
15 participants
INTERVENTIONAL
Albuquerque, United States
Started: Jan 15, 2025
Cannabidiol in the Treatment of Opioid Use Disorder
NCT06206291COMPLETEDPHASE2
141 participants
INTERVENTIONAL
New York, United States
Started: Oct 4, 2023
Assessment of Methadone and Buprenorphine in Interstitial Fluid
NCT05546229COMPLETED
11 participants
OBSERVATIONAL
Lemon Grove, United States
Started: Sep 14, 2022
Harnessing Placebo Effects in Methadone Treatment
NCT02941809COMPLETEDNA
133 participants
INTERVENTIONAL
Baltimore, United States
Started: Dec 5, 2017
Showing 20 of 126 total trials