Acetaminophen (Paracetamol)
Treatment for Osteoarthritis
Typical Dosage: 325-1000mg up to 4x daily, max 4000mg/day
Effectiveness
60%
Safety Score
80%
Clinical Trials
72
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
325-1000mg up to 4x daily, max 4000mg/day
Time to Effect
30-60 minutes
Treatment Duration
As needed or daily for chronic pain
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$1,200
Side Effect Mgmt:$0
Total Annual:$1,230
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$55
Comparison vs No treatment
Cost Difference
+$30/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Acetaminophen (Paracetamol) Outcomes
for Osteoarthritis
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+55%
Common Side Effects
Nausea
+7%
Liver damage (with overdose)
+0.1%
Sources:
Active Clinical Trials
1 active trial recruiting for Acetaminophen (Paracetamol) in Osteoarthritis
Efficacy and Safety of Celecoxib/Acetaminophen Versus Celecoxib for Diagnosed Osteoarthritis in Acute Exacerbation
NCT06863636RECRUITINGPHASE3
231 participants
INTERVENTIONAL
Mexico City, Mexico
Started: Sep 9, 2024
Completed Clinical Trials
16 completed trials for Acetaminophen (Paracetamol) in Osteoarthritis
Time of Intravenous Acetaminophen Administration
NCT01699815COMPLETEDPHASE4
126 participants
INTERVENTIONAL
Durham, United States
Started: Oct 1, 2012
A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
NCT00240773COMPLETEDPHASE3
581 participants
INTERVENTIONAL
Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty
NCT02839876COMPLETEDPHASE4
81 participants
INTERVENTIONAL
Durham, United States
Started: Mar 14, 2017
A Study of the Tolerability of Titrated Dose Tramadol/Acetaminophen Combination Tablet in Korean Patients With Osteoarthritis
NCT01063842COMPLETEDPHASE4
250 participants
INTERVENTIONAL
Started: Aug 1, 2005
A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee
NCT00568295COMPLETEDPHASE3
403 participants
INTERVENTIONAL
Started: Oct 1, 1999
An Effectiveness and Safety Study of Two Doses of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee
NCT00240786COMPLETEDPHASE3
483 participants
INTERVENTIONAL
Started: Apr 1, 2002
Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
NCT02700451COMPLETEDNA
178 participants
INTERVENTIONAL
New York, United States
Started: Mar 1, 2016
Glucosamine Unum In Die [Once A Day] Efficacy (GUIDE) Trial: Glucosamine Sulfate in Patients With Knee Osteoarthritis
NCT00110474COMPLETEDPHASE3
300 participants
INTERVENTIONAL
Coimbra, Portugal +12 more
Started: May 1, 2000
An Effectiveness and Safety Study of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee.
NCT00240799COMPLETEDPHASE3
542 participants
INTERVENTIONAL
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
NCT00635349COMPLETEDPHASE4
143 participants
INTERVENTIONAL
Started: May 1, 2007
Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
NCT00411190COMPLETEDPHASE1
32 participants
INTERVENTIONAL
Antwerp, Belgium +1 more
Started: Oct 19, 2006
Assess the Blood-Oxygen-Level-Dependent (BOLD) Signal Changes in the Brain by Paracetamol as Measured by Functional Magnetic Resonance Imaging (fMRI) in Subjects With Osteoarthritis (OA)
NCT01105936COMPLETEDPHASE4
31 participants
INTERVENTIONAL
Barcelona, Spain
Started: Sep 1, 2010
Effects Of Native Collagen Type 2 Treatment
NCT02237989COMPLETEDNA
39 participants
INTERVENTIONAL
Started: Jan 1, 2013
A Study for Moderate Osteoarthritis of the Knee
NCT01478997COMPLETEDPHASE1, PHASE2
76 participants
INTERVENTIONAL
Nashik, India +1 more
Started: Aug 1, 2011
Comparison of Acetaminophen and PRP Therapy for Knee OA
NCT01782885COMPLETEDNA
543 participants
INTERVENTIONAL
Monterrey, Mexico
Started: May 1, 2013
A Study of Pain Relief in Osteoarthritis
NCT00298974COMPLETEDPHASE3
873 participants
INTERVENTIONAL
Birmingham, United States +82 more
Started: Feb 1, 2006
Showing 20 of 73 total trials