DFDA

Duloxetine (SNRI)

Treatment for Osteoarthritis

Typical Dosage: 30-60mg daily

Effectiveness
68%
Safety Score
60%
Clinical Trials
3
Participants
10K

Comparative Safety Scale(Higher is safer)

Cyanide☠
Meth💀
Cigarettes🚬
Chemo☢
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
30-60mg daily
Time to Effect
2-4 weeks
Treatment Duration
Ongoing
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$900
Monitoring:$1,200
Side Effect Mgmt:$100
Total Annual:$2,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$40,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,818
Comparison vs Oral NSAIDs
Cost Difference
+$625/year
More expensive
QALY Difference
-0.01 QALYs
Worse outcomes
Dominance
No dominance
Duloxetine (SNRI) Outcomes

for Osteoarthritis

Efficacy Outcomes
Overall Effectiveness
+68%
Response Rate
+55%
Common Side Effects
Nausea
+15%
Dry mouth
+12%
Constipation
+12%
Fatigue/insomnia
+7%
Dizziness
+7%
Increased blood pressure
+3%

Sources:

nih.gov
researchgate.net
frontiersin.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
3 completed trials for Duloxetine (SNRI) in Osteoarthritis

Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty

NCT06837012COMPLETEDPHASE4
View Study
106 participants
INTERVENTIONAL
Mumbai, India
Started: Jan 1, 2021

Exercise Plus Duloxetine for Knee Osteoarthritis

NCT04111627COMPLETEDPHASE2
View Study
43 participants
INTERVENTIONAL
Baltimore, United States
Started: Oct 7, 2021

A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain

NCT04224584COMPLETEDPHASE2
View Study
40 participants
INTERVENTIONAL
Aalborg, Denmark
Started: Jan 1, 2020