Oral NSAIDs (e.g., Ibuprofen, Naproxen)
Treatment for Osteoarthritis
Typical Dosage: Ibuprofen 200-800mg 3x daily, Naproxen 250-500mg 2x daily
Effectiveness
75%
Safety Score
75%
Clinical Trials
1,500
Participants
300K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
Ibuprofen 200-800mg 3x daily, Naproxen 250-500mg 2x daily
Time to Effect
Immediate to 1-2 days
Treatment Duration
As needed or daily for chronic pain
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
150(Treat 150 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$100
Side Effect Mgmt:$200
Total Annual:$375
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$577
Comparison vs Acetaminophen
Cost Difference
+$50/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
Oral NSAIDs (e.g., Ibuprofen, Naproxen) Outcomes
for Osteoarthritis
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+65%
Common Side Effects
GI upset (nausea, heartburn)
+15%
GI bleed/ulcer
+3%
Increased blood pressure
+7%
Kidney dysfunction
+3%
Cardiovascular events
+0.75%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov