Weight Management (Diet & Exercise)
Treatment for Osteoarthritis
Typical Dosage: Achieve 5-10% body weight loss, then maintain
Effectiveness
88%
Safety Score
95%
Clinical Trials
16
Participants
80K
Comparative Safety Scale(Higher is safer)
Cyanideโ ๏ธ
Meth๐
Cigarettes๐ฌ
Chemoโข๏ธ
Alcohol๐บ
Morphine๐
Antibiotics๐
Tylenol๐
Exercise๐
Water๐ง
95
DangerousModerateSafe
Treatment Details
Dosage Range
Achieve 5-10% body weight loss, then maintain
Time to Effect
3-6 months
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,200
Side Effect Mgmt:$0
Total Annual:$1,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$-5,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$667
Comparison vs No treatment / Usual care
Cost Difference
$-2,000/year
Less expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Weight Management (Diet & Exercise) Outcomes
for Osteoarthritis
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Common Side Effects
Fatigue/hunger (initial)
+25%
Nutrient deficiencies (if diet not well-balanced)
+0.5%
Active Clinical Trials
3 active trials recruiting for Weight Management (Diet & Exercise) in Osteoarthritis
Predicting The Right Advice at The Right Time in Patients With Hip and Knee OsteoArthritis: the e-cOAch Cross-over.
NCT07423858RECRUITINGNA
600 participants
INTERVENTIONAL
Utrecht, Netherlands
Started: Sep 1, 2025
The NTU JO-SMART Study
NCT07317310RECRUITINGNA
312 participants
INTERVENTIONAL
Taipei, Taiwan +1 more
Started: Aug 1, 2026
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
NCT06807970ACTIVE NOT RECRUITINGEARLY_PHASE1
54 participants
INTERVENTIONAL
Hong Kong, Hong Kong
Started: Sep 1, 2025
Completed Clinical Trials
13 completed trials for Weight Management (Diet & Exercise) in Osteoarthritis
Effects of Glucosamine and Chondroitin Supplementation in Women With Knee Osteoarthritis Participating in an Exercise and Weight Loss Program
NCT01271218COMPLETEDPHASE4
36 participants
INTERVENTIONAL
College Station, United States
Started: Nov 1, 2005
Activity, Rheumatoid and Osteoarthritis, and Weight Management
NCT00365404COMPLETEDNA
465 participants
INTERVENTIONAL
Saint Louis Park, United States
Started: Oct 1, 2003
Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients
NCT02835326COMPLETEDNA
227 participants
INTERVENTIONAL
Columbus, United States
Started: Oct 1, 2016
Home-Based Exercise and Weight Control Program for Pain Control in Overweight Elderly With Osteoarthritis of the Knee
NCT00126737COMPLETEDNA
110 participants
INTERVENTIONAL
Hines, United States
Started: Oct 1, 2002
Effects of a Weight Loss Program in People With Hip Osteoarthritis
NCT04825483COMPLETEDNA
101 participants
INTERVENTIONAL
Carlton, Australia
Started: Jun 16, 2021
Adherence to Treatment in Egyptian Patients With Knee Osteoarthritis
NCT06064253COMPLETEDNA
154 participants
INTERVENTIONAL
Zagazig, Egypt
Started: Jan 12, 2023
Patient and Provider Interventions for Managing Osteoarthritis in Primary Care
NCT01435109COMPLETEDNA
537 participants
INTERVENTIONAL
Durham, United States
Started: Jul 1, 2011
Reducing Obesity and Cartilage Compression in Knees
NCT04730557COMPLETEDNA
88 participants
INTERVENTIONAL
Durham, United States
Started: Jun 5, 2020
Patient and Provider Interventions for Managing Osteoarthritis in Primary Care
NCT01130740COMPLETEDNA
300 participants
INTERVENTIONAL
Durham, United States
Started: Aug 1, 2011
A Comparison Between GLA:D Canada and an Individualized JointEffort Exercise Program in Knee Osteoarthritis Patients
NCT03406767COMPLETEDNA
51 participants
INTERVENTIONAL
Calgary, Canada +3 more
Started: May 1, 2018
Fit and Strong! Plus Comparative Effectiveness Trial
NCT03180008COMPLETEDNA
413 participants
INTERVENTIONAL
Chicago, United States
Started: Dec 1, 2012
Effect of Learning Instruction Package on Patients' Knee Osteoarthritis Outcomes
NCT07326917COMPLETEDNA
71 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Sep 1, 2024
Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA
NCT04910048COMPLETEDNA
46 participants
INTERVENTIONAL
Little Rock, United States
Started: Jan 17, 2022