Amoxicillin
Treatment for Otitis Media
Typical Dosage: 80-90 mg/kg/day in 2-3 divided doses
Effectiveness
75%
Safety Score
70%
Clinical Trials
18
Participants
100K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
80-90 mg/kg/day in 2-3 divided doses
Time to Effect
2-3 days
Treatment Duration
5-10 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10
Monitoring:$50
Side Effect Mgmt:$10
Total Annual:$70
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$120,000/QALY
QALYs Gained
0.01
Outcome-Based Costs
Cost per Responder
$88
Cost per Remission
$93
Comparison vs Watchful Waiting
Cost Difference
+$15/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Physician Visit Cost
$150/year
Time Cost
$50/year
Travel + wait time
Insurance Admin Cost
$15/year
Prior auth, claims
Rx Price
$10/year
Risk Assessment
Misuse Risk
HIGHMissed Diagnosis Risk
LOWAmoxicillin Outcomes
for Otitis Media
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+80%
Remission Rate
+75%
Common Side Effects
Diarrhea
+15%
Rash
+7%
Nausea/Vomiting
+3%
Active Clinical Trials
2 active trials recruiting for Amoxicillin in Otitis Media
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)
NCT07730814NOT YET RECRUITINGPHASE4
1.1K participants
INTERVENTIONAL
Denver, United States +4 more
Started: Oct 1, 2026
Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in Children
NCT06895135NOT YET RECRUITINGNA
162 participants
INTERVENTIONAL
Started: May 1, 2025
Completed Clinical Trials
15 completed trials for Amoxicillin in Otitis Media
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
NCT00539149COMPLETEDPHASE4
126 participants
INTERVENTIONAL
Darwin, Australia
Started: Apr 1, 1996
Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children
NCT02935374COMPLETEDPHASE4
73 participants
INTERVENTIONAL
Oulu, Finland
Started: Nov 1, 2016
Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media
NCT00051753COMPLETEDPHASE3
1.64K participants
INTERVENTIONAL
Started: Nov 1, 2002
Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry
NCT01244581COMPLETEDPHASE3
84 participants
INTERVENTIONAL
Oulu, Finland +1 more
Started: Sep 1, 1999
Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media
NCT02630992COMPLETEDPHASE3
112 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Dec 1, 2015
Acute Otitis Media (AOM) Therapy Trial in Young Children
NCT00377260COMPLETEDPHASE4
291 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Nov 1, 2006
A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media
NCT00644943COMPLETEDPHASE4
425 participants
INTERVENTIONAL
Birmingham, United States +31 more
Started: Feb 1, 2003
A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months
NCT03818815COMPLETEDPHASE2
103 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Feb 21, 2019
A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections
NCT00643292COMPLETEDPHASE3
902 participants
INTERVENTIONAL
Jonesboro, United States +47 more
Started: Jan 1, 2003
Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media
NCT02567825COMPLETEDNA
250 participants
INTERVENTIONAL
Washington D.C., United States +1 more
Started: Nov 1, 2015
Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)
NCT01406275COMPLETED
363 participants
OBSERVATIONAL
Started: Jan 1, 2008
Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study)
NCT07015736COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Eskişehir, Turkey (Türkiye) +3 more
Started: Aug 1, 2025
Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Otitis Media in India
NCT04600752COMPLETEDPHASE4
310 participants
INTERVENTIONAL
Raipur, India +12 more
Started: May 7, 2022
Comparative Effectiveness of Antibiotics for Respiratory Infections
NCT02297815COMPLETED
2.47K participants
OBSERVATIONAL
Philadelphia, United States
Started: Jan 1, 2014
LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
NCT05804123COMPLETEDNA
175 participants
INTERVENTIONAL
Thái Bình, Vietnam
Started: Oct 28, 2021