Stereotactic Body Radiation Therapy (SBRT)
Treatment for Pancreatic Cancer
Typical Dosage: 25-40 Gy in 1-5 fractions
Effectiveness
70%
Safety Score
40%
Clinical Trials
119
Participants
2K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
25-40 Gy in 1-5 fractions
Time to Effect
Weeks to months for local control
Treatment Duration
1-2 weeks (1-5 fractions)
Evidence Quality
MODERATEConfidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$5,000
Side Effect Mgmt:$5,000
Total Annual:$40,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$55,000/QALY
QALYs Gained
0.5
Comparison vs Conventional Radiation Therapy
Cost Difference
+$20,000/year
More expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
No dominance
Stereotactic Body Radiation Therapy (SBRT) Outcomes
for Pancreatic Cancer
Efficacy Outcomes
Overall Effectiveness
+70%
Common Side Effects
Fatigue
+25%
Nausea/Vomiting
+15%
Diarrhea
+10%
Duodenal ulceration/bleeding (late effect)
+3%
Sources:
Active Clinical Trials
9 active trials recruiting for Stereotactic Body Radiation Therapy (SBRT) in Pancreatic Cancer
Stereotactic PAncreatic RadioTherapy Adjuvant Therapy
NCT05043857ACTIVE NOT RECRUITINGNA
50 participants
INTERVENTIONAL
Rozzano, Italy
Started: Jul 6, 2021
Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma
NCT06691425RECRUITINGNA
160 participants
INTERVENTIONAL
Edegem, Belgium +8 more
Started: Jul 19, 2024
Span-C-SBRT for Pancreatic Cancer
NCT03505229ACTIVE NOT RECRUITINGNA
30 participants
INTERVENTIONAL
St Leonards, Australia
Started: Dec 18, 2018
Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma
NCT07126158RECRUITINGPHASE2
36 participants
INTERVENTIONAL
St Louis, United States
Started: Apr 10, 2026
Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma
NCT03991962ACTIVE NOT RECRUITINGPHASE2
28 participants
INTERVENTIONAL
New Haven, United States
Started: Sep 24, 2019
Radiotherapy in Combination With TTI-101 in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma
NCT06141031RECRUITINGPHASE1
24 participants
INTERVENTIONAL
Aurora, United States +1 more
Started: Jan 16, 2024
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma
NCT04331041ACTIVE NOT RECRUITINGPHASE2
42 participants
INTERVENTIONAL
St Louis, United States
Started: Aug 24, 2021
SBRT Combined With Zimberelimab (GLS-010) in Locally Advanced Pancreatic Cancer (SPARK-1 Study)
NCT06009029NOT YET RECRUITINGPHASE2
96 participants
INTERVENTIONAL
Started: Aug 1, 2023
Stereotactic Body Radiotherapy and NALIRIFOX for Locally Advanced Pancreatic Cancer
NCT07173387ACTIVE NOT RECRUITINGPHASE2
42 participants
INTERVENTIONAL
Jinan, China
Started: Oct 1, 2025
Completed Clinical Trials
6 completed trials for Stereotactic Body Radiation Therapy (SBRT) in Pancreatic Cancer
SBRT for Liver Tumors, Liver Metastases, and Pancreatic Tumors
NCT07407257COMPLETEDNA
65 participants
INTERVENTIONAL
Ljubljana, Slovenia
Started: Jan 1, 2019
Pilot Dose Escalation Trial of Stereotactic Body Radiation Therapy (SBRT) in Combination With GC4419 in Pancreatic Cancer
NCT03340974COMPLETEDPHASE1, PHASE2
42 participants
INTERVENTIONAL
Tampa, United States +5 more
Started: Feb 12, 2018
SBRT for Close or Positive Margins After Resection of Pancreatic Adenocarcinoma
NCT01357525COMPLETEDNA
50 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Feb 6, 2013
Phase I Study of Stereotactic Body Radiation Therapy and FOLFIRINOX in the Neoadjuvant Therapy of Pancreatic Cancer
NCT01446458COMPLETEDPHASE1
13 participants
INTERVENTIONAL
Atlanta, United States +1 more
Started: Nov 1, 2011
A Dose Escalation Trial of Stereotactic Body Radiotherapy (SBRT) After Induction Chemotherapy for Locally Advanced Pancreatic Cancer
NCT02643498COMPLETEDPHASE1
11 participants
INTERVENTIONAL
Basking Ridge, United States +6 more
Started: Dec 1, 2015
Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma
NCT01781728COMPLETEDPHASE2
48 participants
INTERVENTIONAL
Baltimore, United States
Started: Jan 1, 2013
Showing 20 of 131 total trials