Stereotactic Body Radiation Therapy (SBRT)
Treatment for Pancreatic Cancer
Typical Dosage: 25-40 Gy in 1-5 fractions
Effectiveness
70%
Safety Score
40%
Clinical Trials
119
Participants
2K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
25-40 Gy in 1-5 fractions
Time to Effect
Weeks to months for local control
Treatment Duration
1-2 weeks (1-5 fractions)
Evidence Quality
MODERATEConfidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$5,000
Side Effect Mgmt:$5,000
Total Annual:$40,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$55,000/QALY
QALYs Gained
0.5
Comparison vs Conventional Radiation Therapy
Cost Difference
+$20,000/year
More expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
No dominance
Stereotactic Body Radiation Therapy (SBRT) Outcomes
for Pancreatic Cancer
Efficacy Outcomes
Overall Effectiveness
+70%
Common Side Effects
Fatigue
+25%
Nausea/Vomiting
+15%
Diarrhea
+10%
Duodenal ulceration/bleeding (late effect)
+3%
Sources:
Active Clinical Trials
10 active trials recruiting for Stereotactic Body Radiation Therapy (SBRT) in Pancreatic Cancer
Stereotactic PAncreatic RadioTherapy Adjuvant Therapy
NCT05043857ACTIVE NOT RECRUITINGNA
50 participants
INTERVENTIONAL
Rozzano, Italy
Started: Jul 6, 2021
Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma
NCT06691425RECRUITINGNA
160 participants
INTERVENTIONAL
Edegem, Belgium +8 more
Started: Jul 19, 2024
Span-C-SBRT for Pancreatic Cancer
NCT03505229RECRUITINGNA
40 participants
INTERVENTIONAL
St Leonards, Australia
Started: Dec 18, 2018
Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma
NCT07126158NOT YET RECRUITINGPHASE2
36 participants
INTERVENTIONAL
St Louis, United States
Started: Apr 30, 2026
Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma
NCT03991962ACTIVE NOT RECRUITINGPHASE2
28 participants
INTERVENTIONAL
New Haven, United States
Started: Sep 24, 2019
SBRT Combined With Zimberelimab (GLS-010) in Locally Advanced Pancreatic Cancer (SPARK-1 Study)
NCT06009029NOT YET RECRUITINGPHASE2
96 participants
INTERVENTIONAL
Started: Aug 1, 2023
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma
NCT04331041ACTIVE NOT RECRUITINGPHASE2
42 participants
INTERVENTIONAL
St Louis, United States
Started: Aug 24, 2021
SBRT Combined With Nimotuzumab and Mono-chemotherapy in Locally Advanced Pancreatic Cancer
NCT06422156NOT YET RECRUITINGPHASE2
73 participants
INTERVENTIONAL
Started: Jun 1, 2024
Stereotactic Body Radiotherapy and NALIRIFOX for Locally Advanced Pancreatic Cancer: A Prospective Clinical Trial
NCT07173387NOT YET RECRUITINGPHASE2
42 participants
INTERVENTIONAL
Jinan, China
Started: Oct 1, 2025
Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma
NCT03704662RECRUITINGNA
102 participants
INTERVENTIONAL
Milwaukee, United States
Started: Oct 22, 2018
Completed Clinical Trials
6 completed trials for Stereotactic Body Radiation Therapy (SBRT) in Pancreatic Cancer
Pilot Dose Escalation Trial of Stereotactic Body Radiation Therapy (SBRT) in Combination With GC4419 in Pancreatic Cancer
NCT03340974COMPLETEDPHASE1, PHASE2
42 participants
INTERVENTIONAL
Tampa, United States +5 more
Started: Feb 12, 2018
SBRT for Close or Positive Margins After Resection of Pancreatic Adenocarcinoma
NCT01357525COMPLETEDNA
50 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Feb 6, 2013
Phase I Study of Stereotactic Body Radiation Therapy and FOLFIRINOX in the Neoadjuvant Therapy of Pancreatic Cancer
NCT01446458COMPLETEDPHASE1
13 participants
INTERVENTIONAL
Atlanta, United States +1 more
Started: Nov 1, 2011
A Dose Escalation Trial of Stereotactic Body Radiotherapy (SBRT) After Induction Chemotherapy for Locally Advanced Pancreatic Cancer
NCT02643498COMPLETEDPHASE1
11 participants
INTERVENTIONAL
Basking Ridge, United States +6 more
Started: Dec 1, 2015
Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma
NCT01781728COMPLETEDPHASE2
48 participants
INTERVENTIONAL
Baltimore, United States
Started: Jan 1, 2013
SBRT Pre-operatively for Pancreatic Cancer
NCT02308722COMPLETEDPHASE1
12 participants
INTERVENTIONAL
Glasgow, United Kingdom +4 more
Started: Apr 1, 2015
Showing 20 of 120 total trials