DFDA

Pancreatic Enzyme Replacement Therapy (PERT)

Treatment for Pancreatitis

Typical Dosage: 25,000-80,000 lipase units per meal/snack

Effectiveness
85%
Safety Score
85%
Clinical Trials
4
Participants
25K

Comparative Safety Scale(Higher is safer)

Cyanideโ˜ ๏ธ
Meth๐Ÿ’€
Cigarettes๐Ÿšฌ
Chemoโ˜ข๏ธ
Alcohol๐Ÿบ
Morphine๐Ÿ’Š
Antibiotics๐Ÿ’‰
Tylenol๐Ÿ’Š
Exercise๐Ÿƒ
Water๐Ÿ’ง
85
DangerousModerateSafe
Treatment Details
Dosage Range
25,000-80,000 lipase units per meal/snack
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10,000
Monitoring:$300
Side Effect Mgmt:$100
Total Annual:$10,400
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$70,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$12,235.29
Prescription Access Economics
Annual Societal Loss per Patient
$8,000
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$100/year
Travel + wait time
Insurance Admin Cost
$50/year
Prior auth, claims
Rx Price
$10,000/year
Potential OTC Price
$2,500/year
Estimated if OTC available
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Requires Monitoring
Yes
Needs lab work/checkups
Pancreatic Enzyme Replacement Therapy (PERT) Outcomes

for Pancreatitis

Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Common Side Effects
Abdominal pain
+15%
Flatulence
+10%
Diarrhea
+7%

Sources:

droracle.ai
bmj.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
4 active trials recruiting for Pancreatic Enzyme Replacement Therapy (PERT) in Pancreatitis

Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis

NCT07418593RECRUITINGPHASE4
View Study
80 participants
INTERVENTIONAL
Baltimore, United States +1 more
Started: Apr 20, 2026

PERT in Acute Necrotizing Pancreatitis

NCT07211568NOT YET RECRUITINGPHASE3
View Study
188 participants
INTERVENTIONAL
Started: Oct 1, 2025

Medication Adherence to Phone-supervised Pancreatic Enzyme Replacement Therapy

NCT06581653ACTIVE NOT RECRUITINGNA
View Study
204 participants
INTERVENTIONAL
Shanghai, China
Started: Aug 15, 2024

Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

NCT06477159RECRUITINGPHASE4
View Study
30 participants
INTERVENTIONAL
Los Angeles, United States +5 more
Started: Feb 1, 2024