Deep Brain Stimulation (DBS)
Treatment for Parkinson S Disease
Typical Dosage: Programmable stimulation parameters
Effectiveness
88%
Safety Score
45%
Clinical Trials
336
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
Programmable stimulation parameters
Time to Effect
Days to weeks (post-activation)
Treatment Duration
Lifetime (with battery replacement every 3-5 years)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$6,000
Side Effect Mgmt:$500
Total Annual:$14,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$90,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$17,500
Comparison vs Optimal Medical Therapy
Cost Difference
+$18,000/year
More expensive
QALY Difference
+0.15 QALYs
Better outcomes
Dominance
No dominance
Deep Brain Stimulation (DBS) Outcomes
for Parkinson S Disease
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+80%
Common Side Effects
Infection
+7%
Intracranial hemorrhage
+3%
Device-related complications
+10%
Speech/swallowing issues
+7%
Sources:
Active Clinical Trials
5 active trials recruiting for Deep Brain Stimulation (DBS) in Parkinson S Disease
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
NCT02071134RECRUITING
1.5K participants
OBSERVATIONAL
Aliso Viejo, United States +83 more
Started: Mar 4, 2014
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
NCT06911229RECRUITINGNA
60 participants
INTERVENTIONAL
Gainesville, United States
Started: Aug 1, 2025
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
NCT05557864RECRUITINGNA
24 participants
INTERVENTIONAL
Minneapolis, United States
Started: Aug 25, 2016
Closed-Loop Therapeutic Refinement Using Local Field Potentials in Parkinson's Disease
NCT07105280NOT YET RECRUITINGNA
30 participants
INTERVENTIONAL
Amsterdam, Netherlands +1 more
Started: Oct 1, 2025
Sleep-specific DBS Therapy in Parkinson's Disease
NCT05962489RECRUITINGNA
64 participants
INTERVENTIONAL
Minneapolis, United States
Started: Jun 22, 2023
Completed Clinical Trials
9 completed trials for Deep Brain Stimulation (DBS) in Parkinson S Disease
Deep Brain Stimulation for Parkinson's Disease Trial
NCT00053625COMPLETEDPHASE3
123 participants
INTERVENTIONAL
Atlanta, United States +1 more
Started: Jun 1, 1999
Effects of Deep Brain Stimulation (DBS) Frequency on Neural Synchrony
NCT02304848COMPLETEDNA
9 participants
INTERVENTIONAL
Stanford, United States
Started: Oct 1, 2012
Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS
NCT02549859COMPLETEDNA
11 participants
INTERVENTIONAL
Chicago, United States
Started: Aug 1, 2015
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
NCT01839396COMPLETEDNA
313 participants
INTERVENTIONAL
Phoenix, United States +21 more
Started: May 17, 2013
Clinical Outcomes of Deep Brain Stimulator (DBS) Electrodes Placed Using Intraoperative Computed Tomography (CT) and Frameless Stereotaxis
NCT01703598COMPLETEDNA
69 participants
INTERVENTIONAL
Portland, United States
Started: Sep 1, 2011
Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease
NCT04184791COMPLETEDNA
24 participants
INTERVENTIONAL
Great Neck, United States
Started: Jan 15, 2020
Uncovering an Electrical Biomarker for Freezing of Gait in Parkinson's Disease
NCT02548897COMPLETEDNA
5 participants
INTERVENTIONAL
Gainesville, United States
Started: Oct 1, 2015
Development and Validation of a Scale Measuring Preoperative Expectations in Parkinson's Disease
NCT04933513COMPLETED
22 participants
OBSERVATIONAL
Nancy, France
Started: Mar 30, 2022
INfusion VErsus STimulation in Parkinson's Disease
NCT02480803COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Amsterdam, Netherlands
Started: Dec 19, 2014
Showing 20 of 347 total trials